非哺乳期乳腺炎的免疫学研究进展

Immunological studies about the progress of non-lactating mastitis

关键词:  非哺乳期乳腺炎  肉芽肿性乳腺炎  浆细胞性乳腺炎  肿瘤坏死因子-α  NK细胞  干扰素-γ  CD4＋T细胞亚群  树突状细胞  趋化因子

Key words:  [Key words] non-lactation mastitis  granulomatous mastitis  plasma cell mastitis  tumor necrosis factor-α  NK cells  interferon-γ  CD4+Tcell subsets  dendritic cells  chemokine

摘要:

[摘要]　乳腺慢性炎症是一种临床上较少见的乳腺炎性疾病，又称非哺乳期乳腺炎，近几年发病率有明显上升趋势。但由于临床医生对该病认识不足，且病因不明，从而导致目前对该病的检出率低，治愈率低。目前认为非哺乳期乳腺炎是一个免疫相关性疾病，有多种细胞及细胞因子参与疾病的发生、发展过程。各类细胞因子在非哺乳期乳腺炎的疾病进展的不同阶段，其血浆含量不同，并有一定规律。本文就肿瘤坏死因子-α，NK细胞，干扰素-γ，CD4＋T细胞亚群，树突状细胞及趋化因子与非哺乳期乳腺炎之间的关系进行综述。

Abstract:

[Abstract] Chronic inflammation of the mammary gland，also known as non-lactating mastitis，is a rare kind of clinical mastitis disease，the incidence of which is on the rise in recent years. Due to the cause is unknown， the detected rate and cure rate are at low levels.Now think of nonpuerperal mastitis is a related immune diseases, has a variety of cells and cytokines involved in the occurrence and development of disease process. All kinds of cytokines in nonpuerperal mastitis of the various stages of disease progression, different levels of plasma, and has certain regularity.In this paper, the tumor necrosis factor alpha, NK cells, interferon-gamma, CD4+T cells, dendritic cells and chemokines, and summarized the relationship between nonpuerperal mastitis.