化疗致多器官损伤中细胞因子的作用及应对策略

Role of cytokines in multiple organ injury induced by chemotherapy and coping strategies

关键词:  化疗  毒副作用  细胞因子  拮抗剂

Key words:  [Key words] chemotherapy  side effect  cytokine  antagonist

摘要:

[摘要]　化疗是治疗恶性肿瘤的方法之一，随着肿瘤发病率和各类抗癌药物应用的逐年上升，化疗药物严重的毒副作用更显突出，高效抗癌作用与随之而来的毒副作用的矛盾，成为临床化疗的最大阻力。研究化疗药物毒副作用的机制，寻找有效的缓解方法，探索副作用小的新抗癌疗法，成为当今科学研究的热点。对顺铂所致肾毒性、吉非替尼所致间质性肺炎等典型化疗副作用的免疫学机制研究表明，炎性细胞和细胞因子在器官损伤中比药物本身发挥更重要作用。本文对化疗药物所致的几种常见的器官功能损伤，如肾毒性、肺纤维化、肝脏毒性中细胞因子的研究进展进行综述，为相关拮抗剂的临床应用提供理论依据。

Abstract:

[Abstract] Chemotherapy is one of the best ways to treat malignant tumors that affect human health. In addition to efficient anti-cancer effects, the application of different anti-cancer drugs has serious side effects and consequently toxic effects which create the largest clinical resistance to chemotherapy. It has today become a hot area of research to study the mechanism of toxicity of chemotherapeutic drugs, to find effective mitigation methods, and to explore side effects of new anti-cancer therapies. Studies on typical side effects of chemotherapy such as cisplatin-induced nephrotoxicity, gefitinib-induced interstitial lung disease (ILD) have shown that inflammatory cells and cytokines are involved in organ damage rather than the drugs themselves. This manuscript aims to summarize the regulation of several common chemotherapeutic drug-induced organ dysfunctions, such as renal toxicity, pulmonary fibrosis and liver toxicity and to provide a theoretical basis for clinical application of the relevant cytokines receptor antagonists.