脾虚与物质能量代谢

Spleen deficiency syndrome and substance and energy metabolism

关键词:  脾虚证  物质代谢  能量代谢

Key words:  [Key words]　spleen deficiency syndrome  physical metabolism  energy metabolism

摘要:

中医学认为脾是“后天之本”，“气血生化之源”，现代医学证实脾的生理功能与物质能量代谢之间存在联系。本文综述了脾虚证患者或动物存在的物质能量代谢紊乱，包括葡萄糖、蛋白质、脂质、能量、核酸和水液的代谢障碍，主要体现在糖分解产能的方式发生变化，糖原含量异常，蛋白质合成和分解过程异常，甘油三酯代谢及胆固醇的代谢异常，线粒体形态、数量以及功能发生异常改变，DNA和RNA合成减少，水通道蛋白的表达和功能异常等，对脾虚证与物质能量代谢紊乱的相关性进行评述。本综述对脾虚证机体的物质能量代谢进行分析，将有助于进一步深入理解脾的生理功能和脾虚证的实质。

Abstract:

[Abstract]　Traditional Chinese medicine believes that the spleen is "the foundation of acquired constitution", "source of generating QI and blood" modern medicine confirms that there is a link between spleen physiological functions and energy metabolism. This review described spleen deficiency syndrome patients and animals appear energy metabolism disorders, including abnormal glucose, proteins, lipids, energy, nucleic acids and water solution metabolism, mainly reflected in abnormal glycogen content, glucose decomposition, protein synthesis and decomposition process, increased lipid peroxidation, decreased antioxidant enzyme activity, abnormal changes in the mitochondrial morphology, number and function, reduced synthesis of DNA and RNA, the water channel protein expression and function abnormalities, etc., and thus to investigate the correlation between spleen deficiency syndrome and substance and energy metabolism disorders. Therefore, by the analysis of the energy metabolism of the spleen deficiency will help further understanding of the nature of the physiological function of the spleen and spleen deficiency syndrome.