颌下腺套细胞淋巴瘤病理特点分析

Study of clinical-pathological features for mantle cell lymphoma in submandibular gland

关键词:  颌下腺  套细胞淋巴瘤  诊断

Key words:  submandibular gland  mantle cell lymphoma  diagnosis

摘要:

目的　探讨颌下腺套细胞淋巴瘤（MCL）的病理临床表现、免疫表型特征、在诊断及鉴别诊断中的意义。　方法　对1例颌下腺MCL行组织形态和免疫组化结果观察分析并结合文献归纳颌下腺MCL的病理特点。　结果　本例颌下腺经典型MCL由形态单一的小到中等大的肿瘤性淋巴细胞组成，弥漫排列，核形不规则，有的可见核裂，很像滤泡中心细胞，核分裂像易见,肿瘤细胞间散在无吞噬活性的组织细胞。间质见透明变性小血管。免疫组化:肿瘤细胞CD20（+），CD5（+）,CD43（+），CyclinD1(+), bcl-2(+), CD3(-), CD10(-)，bcl-6(-)，CD23(-)，CD21显示扩大不规则的滤泡树突细胞网（FDC网）。　结论　颌下腺套细胞淋巴瘤有其自身组织学特征，CyclinD1(+)有助于临床诊断。

Abstract:

Objective　To study clinical-pathological and immunophenotypic features for mantle cell lymphoma in submandibular gland which can be used in the diagnosis and differential diagnosis.　Methods　To analyze morphology and immunohistochemitry of one case of mantle cell lymphoma in submandibular gland and to review literature.　Results　The classic mantle cell lymphoma of submandibular gland with diffuse pattern of growth is composed of monomorphous small to medium-sized cells with slightly irregular nuclei which most closely resembled centrocytes. Large scattered epithelioid histiocytes with no tingible bodies and hyalinized venules are distinct. Mitoses are easily found.Immunostaining results for CD5, CD43, CD20, CyclinD1 and bcl-2 are positive and negative for CD3, CD10, bcl-6 and CD23. CD21 staining present large FDC network. 　Conclusion　Mantle cell lymphoma of submandibular gland have distinct histological architectures and Cyclin D1 is specific immunohistochemistric staining for it.