幽门螺杆菌感染与自身免疫性甲状腺炎的相关性研究

Research the relativity of Helicobacter pylori infection and autoimmune thyroiditis

关键词:  幽门螺杆菌（Hp）  自身免疫性甲状腺炎（AT）  抗甲状腺过氧化物酶抗体（TPOAb）  抗甲状腺球蛋白抗体（TgAb）

Key words:  Helicobacter pylori  autoimmune thyroiditis  anti-thyroid peroxidase antibody  antithyroglobulin antibody

摘要:

目的　探讨幽门螺杆菌（Hp）感染与自身免疫性甲状腺炎（AT）的相关性。方法　选取126名AT患者，将AT患者根据甲状腺功能分为A组（甲状腺功能正常）、B组（甲状腺功能亢进）、C 组（甲状腺功能减退），100名与之匹配的对照者（D组）。用免疫酶法测定各组的抗甲状腺过氧化物酶抗体（TPOAb）和抗甲状腺球蛋白抗体（TgAb），用ELISA方法检测各组的抗Hp抗体IgG和IgA。结果　A、B、C、D 4组的Hp感染阳性率分别为71.4%、80%、83.3%和43%。A、B、C 3组均比对照组有更高的Hp感染阳性率，而A、B、C 3组间Hp感染阳性率差异无显著性意义；在AT患者中发现抗Hp抗体与甲状腺自身抗体呈正相关。结论　Hp感染与AT相关，可能是AT的病因之一。

Abstract:

Objective 　To research the relativity of Hp infection and AT. 　Methods 　126 AT patients were chosen and divided into group A (normal thyroid function), group B(hyperthyroidism), and group C (hypothyroidism) according to thyroid function. 100 persons were chosen as control group（group D）, who were matching with AT patients. The levels of TPOAb, TgAb were detected by immunoenzyme method, anti-Hp antibody IgG and anti-Hp antibody IgA in respective group were detected by ELISA method. 　Results 　The positive rate of Hp infection in A, B, C, D group was respectively 71.4%, 80%, 83.3% and 43%. The positive rate of Hp infection was higher in A, B, C group than in control group. Nevertheless, there were no significant differences among A, B, C group. It was found that anti-Hp antibody is positively correlated with thyroid autoantibody in AT patients. 　Conclusion 　Hp infection is relative with AT, it may be one of the causes of AT.