| 摘要: |
| 研究发现，MMR及MGMT蛋白表达缺失与大肠癌等恶性肿瘤的发生密切相关，胃癌及非小细胞肺癌常出现MMR和MGMT蛋白表达增高。本文通过介绍DNA修复系统中ERCC1、XRCC1和MMR、MGMT的作用机制及它们与肿瘤发生和化疗耐药性的关系，提出DNA修复系统关键蛋白的表达降低与肿瘤发生有关，在肿瘤发展过程中也会出现表达增高，且它们表达的增高或降低均与肿瘤化疗耐药性有关。 |
| 关键词: ERCC1 XRCC1 MMR MGMT 肿瘤发生 化疗耐药 |
| DOI：10.11724/jdmu.2012.06.01 |
| 分类号: |
| 基金项目:国家自然科学基金项目（81071805） |
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| Relationship of DNA repair system with tumorigenesis and resistance to chemotherapy |
|
L Shen
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Laboratory Center, the Second Affiliated Hospital of Dalian Medical University, Dalian 116027, China
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| Abstract: |
| Some researchers reported that the deficiency of MMR and MGMT proteins was associated with colorectal cancer and other cancers, and proteins of MMR and MGMT were over-expression in gastric cancer and non-small-cell lung cancer. This article introduces the mechanism of ERCC1，XRCC1，MMR，MGMT and the relationship with tumorigenesis and resistance to chemotherapy, and then suggests that hypo-expression of DNA repair proteins is associated with tumorigenesis and over-expression of them also appears in the development of tumors, and the abnormal expression is associated with resistance to chemotherapy. |
| Key words: ERCC1 XRCC1 MMR MGMT tumorigenesis chemotherapy resistance |
