金属类抗癌药物的研究进展

Metal-based anticancer drug research progress

关键词:  抗癌药物  抗癌活性  金属配合物

Key words:  anti-cancer drugs  anticancer activity  metal complexes

摘要:

在新型抗癌药物中，金属类抗癌药物已成为重要的一类。金属类抗癌药物有许多其它药物无法比拟的独特性质,近年，新的高效、低毒、具有抗癌活性的金属化合物不断被合成出来。其中有铂类抗癌药物，有机锡及其配合物、有机锗化合物、钯配合物、钌配合物、铜配位化合物、钛类化合物等，本文综述了这些化合物在抗癌领域的研究与应用新进展。

Abstract:

In recent years, metal-based anti-cancer drugs have become one important type among the new developing anti-cancer drugs. Metal-based anti-cancer drugs have many unique properties that are superior to those of other drugs. With the further understanding of the pharmacological action of the metal complexes, the new metal compounds with high efficiency, low toxicity, and anticancer activity were continuously synthesized. Those compounds included platinum anti-cancer drugs, organic tin complexes, organic germanium compound, palladium complexes, ruthenium complexes, copper coordination compounds, titanium compounds, etc. This article reviews research and application progress of these compounds in the anti-cancer field.