| 摘要: |
| 体内体外实验研究结果显示TGF-β信号通路作为肿瘤抑制基因，在人类卵巢癌中常常发生遗传突变和表观遗传修饰而失活，丧失对肿瘤细胞的生长抑制作用，反过来卵巢癌细胞分泌TGF-β增加，通过多种机制促进侵袭和转移。针对TGF-β及其信号通路相关分子，大量的靶向治疗药物逐渐被开发应用，在不久的将来，抗TGF-β治疗将成为众多肿瘤治疗新方案之一。本文就TGF-β信号通路与卵巢癌发生、发展及转移的关系进行综述。 |
| 关键词: 卵巢肿瘤 转化生长因子 Smads 转移 肿瘤抑制基因 |
| DOI：10.11724/jdmu.2012.04.26 |
| 分类号: |
| 基金项目: |
|
| Actions of TGF-β in human ovarian cancer |
|
GAO Na 1, WU Tao 21,2
|
|
1. Departmen of Obsteterics and Gynecology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China;2. Department of Oncology, the Second Affiliated Hospital of Dalian Medical University, Dalian 116027, China
|
| Abstract: |
| In this review we try to provide an authoritative account of the action of TGF-β and some of its relative cytokines during ovarian tumor formation, progression and metastasis. Transforming growth factor-beta (TGF-beta) is a secreted polypeptide that signals via receptor serine/threonine kinases and intracellular Smad effectors. TGF-beta inhibits proliferation and induces apoptosis in various cell types, and accumulation of loss-of-function mutations in the TGF-beta receptor or Smad genes classify the pathway as a tumor suppressor in humans. On the other hand, human ovarian tumor overproduce TGF-beta whose autocrine and paracrine actions promote tumor cell invasiveness and metastasis. Current clinical approaches aim at establishing novel cancer drugs whose mechanisms target the TGF-beta pathway. In conclusion, TGF-beta signaling is intimately implicated in ovarian tumor development and contributes to all cardinal features of tumor cell biology. |
| Key words: ovarian tumor TGF-beta Smads metastasis tumor suppressor |
