| 摘要: |
| 阿尔茨海默病（Alzheimer's disease，AD）是一种进行性发展的神经退行性疾病。流行病学显示老年女性更容易患病，这可能与绝经后雌激素水平陡然下降有关。近年来研究发现雌激素的神经保护作用可能与降低AD发生的危险系数有关。本文对雌激素与AD相关的神经保护机制进行综述。 |
| 关键词: 雌激素 阿尔茨海默症 神经保护作用 β淀粉样蛋白 |
| DOI：10.11724/jdmu.2012.03.26 |
| 分类号: |
| 基金项目: |
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| Neuroprotective effects of estrogen in Alzheimer's disease |
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YANG Tao, JIANG Miao-na, JIA Yu-hong
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Department of Pathophysiology, Dalian Medical University, Dalian 116044, China
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| Abstract: |
| Alzheimer's disease (AD) is a progressive neurodegenerative disease. Epidemiological evidence shows older women are more susceptible to AD, which may be related with post-menopausal precipitous depletion of estrogens. Recent researches suggest that the neuroprotective effects of estrogen may be relevant to decrease the risk of AD. This review will make a brief summary on AD-related neuroprotective mechanism of estrogen. |
| Key words: estrogen Alzheimer's disease neuroprotection β-amyloid |
