托烷司琼预防腹腔镜胆囊切除术及胆道手术术后恶心呕吐的临床观察

Clinical observation of the effect of Tropisetron on laparoscopic cholecystectomy and biliary surgery of postoperative nausea and vomiting

关键词:  托烷司琼  腹腔镜  术后  恶心  呕吐

Key words:  tropisetron  laparoscopic  post-operation  nausea  vomiting

摘要:

[目的]观察托烷司琼预防腹腔镜胆囊切除术及胆道手术术后恶心呕吐的效果。[方法]选择2011年3月-6月择期行腹腔镜胆囊切除术及胆道手术患者60例，随机将患者分为对照组和托烷司琼组，每组30例。手术结束后拔管前，对照组静脉给予0.9%氯化钠溶液5 mL,托烷司琼组静脉给予托烷司琼5 mg。观察术后6、12、24、48 h每一时间段患者恶心、呕吐的发生情况。[结果]与对照组比较，托烷司琼组在术后6 h、12 h恶心、呕吐的发生率明显降低（P<0.05或P<0.01）,而在术后24 h和48 h恶心、呕吐的发生率差异无显著性意义。[结论]术毕静注5 mg托烷司琼在24 h内可以很好的预防腹腔镜胆囊切除术及胆道手术术后的恶心、呕吐。为了达到48 h止吐作用，可以适当追加托烷司琼。

Abstract:

[Objective]To investigate the effect of Tropisetron on laparoscopic cholecystectomy and biliary surgery of postoperative nausea and vomiting. [Methods]From March 2011 to June 2011, we collected sixty persons including elective surgery of laparoscopic cholecystectomy and biliary surgery, the patients were divided into control group and Tropisetron group, and each group included 30 cases. Before pulling out the endotracheal tube, intravenous 5mL of Normal Saline in the control group, and the Tropisetron group were given Tropisetron 5 mg. To observe the occurring of nausea and vomiting at 6,12, 24 h and 48 h. [Results]comparing with the control group, nausea and vomiting was significantly decreased at 6 h and12 h （P<0.05 or P<0.01） and there was no statistical differences at 24 h and 48 h in the Tropisetron group. [Conclusion]Intravenous 5 mg Tropisetron could have a good prevention to nausea and vomiting after laparoscopic cholecystectomy and biliary surgery. In order to achieve the effect within 48 h, we could add Tropisetron appropriately.