老年人良性前列腺增生与代谢综合征关系研究

Relationship between benign prostatic hyperplasia and metabolic syndrome in elderly men

关键词:  良性前列腺增生  代谢综合征  老年人

Key words:  benign prostatic hyperplasia  metabolic syndrome  aged

摘要:

[目的] 探讨老年人良性前列腺增生（BPH）与代谢综合征（MS）之间的关系。[方法] 选取81例老年良性前列腺增生患者为观察对象。测量血压、身高、体重、腹围，计算体质指数（BMI），检测糖化血红蛋白(HbAlc)、空腹血糖(FBG)、血脂（TG、TC、HDL-C、LDL-C），根据有无代谢综合征将患者分为代谢综合征组39例和非代谢综合征组42例。测定血清前列腺特异性抗原(PSA)、前列腺体积(PV)，计算前列腺年均增长率、国际前列腺症状评分（IPSS），询问下尿路症状(LUTS)出现时间及是否有急性尿储留史，根据前列腺症状药物治疗(MTOPS)研究的临床进展性评价指标将患者分为低进展组34例与高进展组47例。[结果] 良性前列腺增生合并代谢综合征组PV、PSA、前列腺年增长率、LUTS出现时间、IPSS均高于非代谢综合征组（P<0.05）。良性前列腺增生高进展组BMI、血压、FBG、HbAlc、TG水平均高于低进展组（P<0.05），HDL-C水平低于低进展组（P<0.05）。良性前列腺增生患者PV与FBG、TG呈正相关(r=0.41、0.46，均P<0.01)。IPSS评分与FBG、TG同样呈现正相关(r=0.39、0.23，P<0.01)。[结论] 代谢综合征与老年人前列腺增生发病及进展密切相关。

Abstract:

[Objective] To assess the relationship between benign prostatic hyperplasia and metabolic syndrome in elderly men. [Methods] A total of 81 elderly benign prostatic hyperplasia patients were recruited in this study. The blood pressure，height，body weight and waist circumference were measured，and the BMI was calculated．Biochemical analyses included HbAlc，FBG and blood lipid. According to metabolic syndrome confirmed or not，the patients were divided into two groups：metabolic syndrome group (n=39) and non metabolic syndrome group (n=42).The PSA and PV were measured and its average annual growth rate was calculated，IPSS was evaluated and inquired about the history of LUTS and acute urinary retention in detail．By the evaluation of benign prostatic hyperplasia progressivity, provided from MTOPS study，the patients were divided into low progressive risk group (n=34) and high progressive risk group (n=47)．[Results] The levels of PV，PSA，average annual growth rate，the history of LUTS，IPSS in metabolic syndrome group were higher than those in non metabolic syndrome group（P<0.05）. It showed a higher levels of BMI，blood pressure，FBG，HbAlc，TG and a lower HDL-C levels in high progressive risk group than those in low progressive risk group（P<0.05）. The PV was significantly correlated with blood glucose and TG (r=0.41,0.46，all P<0.01).The IPSS was also positively correlated with blood glucose and TG (r=0.39,0.23，P<0.01). [Conclusions] Metabolic syndrome is related to the onset and development of benign prostatic hyperplasia．