| 摘要: |
| 药物转运体是存在于机体几乎所有器官的跨膜转运蛋白，其功能是主动转运药物。药物转运体的功能变化直接影响药物的吸收、分布、代谢和排泄。在临床上，很多药物联合用药时发生药物相互作用的靶点就是药物转运体。药物转运体介导的药物相互作用与药物疗效、药代动力学及临床安全用药休戚相关。 |
| 关键词: 转运体 药物相互作用 药代动力学 |
| DOI：10.11724/jdmu.2012.01.01 |
| 分类号: |
| 基金项目:国家自然科学基金资助项目（30672498，30873118，81072694）；辽宁省教育厅项目（2008S078，05L112）；辽宁省科技厅项目（2004225003-6）；大连市科委项目（2009E12SF155，2010E12SF060） |
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| Transporter-mediated drug-drug interaction and safe medication in clinic |
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LIU Ke-xin
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Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian 116044, China
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| Abstract: |
| Drug transporters are proteins of transmembrane transportation in all organs of human. Active transport is its major function. The change in function of transporters affects directly the processes of drug absorption, distribution, metabolism and excretion. The transporters on cell membrane are the target sites of drug-drug interaction. Transporter-mediated drug-drug interaction is related to drug therapy, pharmacokinetics and safe medication in clinic. |
| Key words: transporter drug-drug interaction pharmacokinetics |
