| 摘要: |
| Aurora-A是中心体相关激酶，在细胞有丝分裂中起重要作用，可能通过上调癌基因c-myc的表达及抑制抑癌基因p53的作用等使细胞发生恶性转化。Aurora-A过表达是卵巢癌发生中的早期事件，与卵巢癌耐药性的产生及预后差相关。本文重点综述了Aurora-A在卵巢癌的早期诊断、耐药性产生及预后方面的研究进展 。 |
| 关键词: Aurora-A 卵巢癌 早期诊断 耐药性 预后 |
| DOI：10.11724/jdmu.2011.06.22 |
| 分类号: |
| 基金项目:辽宁省教育厅重点实验室项目（2008S079） |
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| Research progress of relationship of Aurora-A with early diagnosis, drug resistance and prognosis of ovarian cancer |
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GAO Bei，HU Jun1,2
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1.Grade 2007 of Seven-Year System, Dalian Medical University, Dalian 116044,China;2.Department of Histology and Embryology, Dalian Medical University, Dalian 116044, China
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| Abstract: |
| Aurora-A is a centrosome-related kinase, which plays an important role in mitosis. It has been found to get the malignant transformation possibly by increasing the expression of c-myc oncogene and inhibiting the effect of cancer suppressor gene p53. The over-expression of Aurora-A in ovarian cancer is an early event, and is related with the ovarian cancer drug resistance and poor prognosis. This review highlights recent progress in the effect of Aurora-A on the early diagnosis, drug resistance and prognosis of ovarian cancer. |
| Key words: Aurora-A ovarian cancer early diagnosis drug resistance prognosis |
