人乳头状瘤病毒、EB病毒感染与子宫颈癌关系研究

Significance of HPV and EBV infections in cervical carcinogenesis

关键词:  子宫颈癌  HPV  EBV

Key words:  cervical cancer  HPV  EBV

摘要:

[目的]探讨人乳头状瘤病毒(HPV)、EB病毒(EBV)在宫颈组织的感染及与宫颈癌发病的关系。[方法]用免疫组织化学染色方法（LSAB）检测50例宫颈癌与20例正常宫颈组织HPV、 EBV的表达，并探讨其与临床病理参数的关系。[结果]宫颈癌组织HPV和EBV 的阳性表达率分别为44.00%和52.00%，二者均明显高于正常宫颈组织的5.00%和10.00%（P<0.05），HPV和EBV 的混合感染率为18.00%（9/50）。HPV阳性表达率未闭经者 （56.25%）明显高于闭经者（28.56%）（P<0.05）；组织学分化3级（87.50%）明显高于1、2级 （20.00%、40.62%）（P<0.05）；临床分期Ⅱ期（85.71%）明显高于临床Ⅰ期（26.66%）（P<0.05）；有淋巴结转移组（77.77%）明显高于无转移组（23.07%）（P<0.05）。EBV阳性表达率未闭经者（65.62%）明显高于已闭经者（27.78%）（P<0.05）；组织学分化1级（90%）明显高于2、3级（43.75%、37.50%）（P<0.05）；临床分期Ⅰ期（86.66%）明显高于临床Ⅱ期的（28.57%）（P<0.05）； 无淋巴结转移组（84.61%）明显高于有转移组（44.44%）（P<0.05）。[结论]HPV、EBV在宫颈癌组织有较高的感染率，二者感染可能均与宫颈癌发病相关。

Abstract:

[Objective] To analyze the significance of HPV and EBV infections in the cervical carcinogenesis. [Methods] The expressions of HPV and EBV were examined by immunohistochemistry in 20 normal cervical tissues and 50 cervical carcinoma tissues．[Results] The positive expression rates of HPV and EBV proteins in cervical carcinoma (44.00% and 52.00%) were significantly higher than those in normal cervical tissues （5.00% and 10.00%）(P<0.05), the combined infection rate of them was 18.00%(9/50). The positive expression rates of HPV in the carcinoma of patients with the non-amenorrhea (56.25%) was significantly higher than that with the amenorrhea (28.56%) (P<0.05). The rates of HPV in histological grade 1, 2 and 3 were 20.00%, 40.62% and 87.50% respectively (P<0.05), the rates in tumor stage 1 and 2 were 26.66% and 85.71%, respectively (P<0.05), and the rates with lymph nodes-metastasis and without were 77.77% and 23.07% (P<0.01). The positive expression rates of EBV in the carcinomas of patents with the non-amenorrhea (65.62%) was significantly higher than that with the amenorrhea (27.78%) (P<0.05). The rates of EBV in histological grade 1, 2 and 3 were 90%, 43.75% and 37.50% respectively (P<0.05), the rates in tumor stage 1 and 2 were 86.66% and 28.57%, respectively (P<0.05), and the rates with lymph nodes-metastasis and without were 44.44% and 84.61% (P<0.01). [Conclusion] There are high incidences of HPV and EBV infection in the cervical carcinomas and the infections would play a role in the development of the cervical carcinoma.