| 摘要: |
| IL-8在人体正常细胞中不表达，但在许多恶性肿瘤细胞中高表达，其中包含大肠癌。IL-8与细胞表面G-蛋白偶联受体（CXCR1 /CXCR2）结合，促进肿瘤细胞生长、血管形成和转移，通过丝氨酸-苏氨酸激酶激活，蛋白酪氨酸激酶（PTK）活化，Rho-鸟苷三磷酸酶（Rho-GTPases）活化等特异信号传导途径成为肿瘤微环境重要调节因子。IL-8受体使表皮生长因子受体（EGFR）配体脱落，激活EGFR参与CXCR1和CXCR2活化过程，正调节IL-8产物，诱导IL-8的表达，并发出促细胞生长信号，促进肿瘤生长、血管生成等。本文对IL-8和IL-8受体CXC1/2在大肠癌的高表达以及对肿瘤生物学的影响进行综述。 |
| 关键词: 大肠癌 白介素8 CXCR1/2 肿瘤生长 血管生成 |
| DOI：10.11724/jdmu.2011.05.25 |
| 分类号: |
| 基金项目: |
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| Regulatory role of IL-8 and its receptor in carcinoma of large intestine |
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ZHAO Zhi1, LI Fang2
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1.Grade 2006, Seven-years Program,Dalian Medical University,Dalian 116044,China;2.Department of Immunology,Dalian Medical University,Dalian 116044,China
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| Abstract: |
| Interleukin 8 (IL-8) does not have expression in normal human cells, and has high expression in many carcinoma cells, including carcinoma of the large intestine. IL-8 is potent promoters of tumor cell proliferation, angiogenesis and metastasis by binding G-protein-coupled receptor (CXCR1/2). Through active serine/threonine kinase, protein tyrosine kinase (PTK), and Rho-guanosine triphosphatase (Rho-GTPases) special signal pathways, it has been demonstrated to be an important regulatory factor in tumor microenvironment. IL-8 receptors can make EGFR ligand to be lost, trigger EGFR in the activation of CXCR1 and CXCR2, adjust IL-8 production positively, induce IL-8 expression, produce cell growth signal, and promote tumor growth and angiogenesis. Here, the high expression of IL-8 and CXCR1/2 in carcinoma of the large intestine and their role in tumor biology are reviewed. |
| Key words: carcinoma of large intestine interleukin-8 CXCR1/2 tumor growth angiogenesis |
