宫颈微腺体增生7例临床病理分析

Cervical microglandular hyperplasia: clinical and pathological analysis of 7 cases

关键词:  微腺体增生  免疫组化  诊断  鉴别诊断

Key words:  microgland hyperplasia  immunohistochemistry  diagnosis criteria  differential diagnosis

摘要:

［目的］探讨宫颈微腺体增生病理组织学特征、诊断标准及鉴别诊断。［方法］采用常规HE染色确定病理诊断的基础上采用免疫组化Envision二步法分析7例宫颈微腺体增生，并结合文献进行临床病理分析。［结果］7例宫颈微腺体增生患者平均年龄41.6岁，其中3例有口服避孕药史；1例病理组织学显示宫颈微腺体增生伴不典型增生。免疫组化显示增生腺体对CEA、P53、Ki-67、P16均不表达。［结论］宫颈微腺体增生属于一种良性宫颈病变，大多数光镜下可明确诊断。对于不典型宫颈微腺体增生，需依靠病理组织形态学特征和免疫组化标记进行诊断。

Abstract:

［Objective］To investigate cervical micro gland hyperplasia istopathological characteristics,diagnostic criteria and differential diagnosis.［Methods］Conventional HE staining and immunohistochemical envision two step analysis of 7 cases of cervical micro gland hyperplasia were used.［Results］Seven cases,in the average age of 41.6 years old,presented cervical micro gland hyperplasia.Three of them had a history of oral contraceptive use and 1 case of the cervical micro gland hyperplasia showed atypical hyperplasia.Immunohistochemistry test indicated that the CEA,P53,Ki-67,P16 were not expressed in hyperplastic glands.［Conclusion］Cervical micro gland hyperplasia is a completely benign cervical lesions.Its diagnosis cam be made under light microscope.For the atypical cervical micro gland hyperplasia,the diagnosis depends on the pathologic morphology and immunohisto- chemical markers.