体检人群脂肪肝与代谢综合征及其组份的相关性分析

Relationship between Fatty Liver and Metabolic Syndrome

关键词:  脂肪肝  代谢综合征  血脂  患病率  相关性

Key words:  fatty liver  metabolic syndrome  serum lipid-profile  prevalence  relevance

摘要:

［目的］了解体检人群脂肪肝的患病情况并分析其与血脂之间的相关性。［方法］收集体检中心8009例健康受检者的临床资料，计算各年龄组脂肪肝的患病率；并按有无脂肪肝分为脂肪肝组和非脂肪肝组，比较两组甘油三酯（TG）、胆固醇（CHOL）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）均值差异有无统计学意义。对脂肪肝与代谢综合征及其组份的相关性进行分析。［结果］ （1）人群脂肪肝患病率为26.0%，其中男性患病率为35.9%，女性患病率为13.2%，两者比较差异有显著性意义（P<0.001）；<50岁年龄组内脂肪肝组CHOL和LDL-C均值均高于非脂肪肝组，>70岁年龄组内，脂肪肝组CHOL均值高于非脂肪组（P<0.001）。（2）各年龄组内脂肪肝组TG均值高于非脂肪肝组，而脂肪肝组HDL-C低于非脂肪肝组，两组比较，P均<0.001。（3）脂肪肝与TG、CHOL、LDL-C、BMI、高血压及高血糖呈正相关，P均<0.001，而与HDL-C呈负相关（P<0.001）。［结论］ （1）人群脂肪肝的男性患病率高于女性；（2）脂肪肝与代谢综合征及其组份具有相关性，血TG、CHOL、LDL-C、血糖、BMI、血压增高是脂肪肝的危险因素，而HDL-C增高是脂肪肝的保护因素。

Abstract:

［Objective］To explore the prevalence of the fatty liver, and to analyze its relationship with metabolic syndrome.［Methods］This cross-sectional study randomly included 8009 people. We computed the prevalence of fatty liver of different age groups. According to the availability of fatty liver, they were divided into fatty liver and non-fatty liver groups, the difference of two groups were compared in triglyceride (TG), cholesterol (CHOL), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). The relationship between fatty liver and its components of metabolic syndrome was analyzed.［Results］(1) The prevalence of the fatty liver was 26.0%, 35.9% in males and 13.2% in females and in comparison the difference was significant statistically (P<0.001). In less than 50 years old age group, the average level of CHOL and LDL-C in fatty liver group was higher than that in non-fatty liver group (P<0.001), and in over 70 years old age group, the average level of CHOL in fatty liver group was higher than that in non-fatty liver group (P<0.001). (2) In every age group, mean TG in fatty liver group was higher than that in non-fatty liver group. HDL-C in fatty liver group was lower than that in non-fatty liver group (P<0.001). (3) The fatty liver was positively correlated with triglyceride, cholesterol, low-density lipoprotein cholesterol BMI, hyperglycemia and hypertension (P<0.001), and negatively correlated with HDL-C (P<0.001).［Conclusions］(1) The prevalence of fatty liver in males is higher than that in females. (2) The fatty liver is associated with metabolic syndrome and its components. TG, CHOL, LDL-C, BMI, hyperglycemia and hypertension are risk factors of fatty liver, while HDL-C is a protective factor of fatty liver.