帕瑞昔布钠麻醉前给药对甲状腺手术患者术后镇痛效果的临床观察

Effect of parecoxib as pre-anesthesia treatment on postoperative pain in thyroid surgery

关键词:  环氧化酶2抑制剂  镇痛  甲状腺手术

Key words:  cyclooxygenase inhibitors  analgesia  thyroid surgery

摘要:

［目的］观察与评价甲状腺手术患者麻醉诱导前应用帕瑞昔布钠术后镇痛的效果。［方法］拟行择期全麻下甲状腺手术患者300例，年龄18～65岁，体重指数17～29 kg/m2，性别不限，ASA分级Ⅰ或Ⅱ级，随机分为两组：生理盐水组（n=150），帕瑞昔布钠组（n=150）。于麻醉诱导前5 min，生理盐水组，帕瑞昔布钠组分别经静脉通路给予生理盐水5 mL，帕瑞昔布钠40 mg。记录术后多时点VAS评分情况，哌替啶使用率，恶心呕吐程度。［结果］与生理盐水组比较，帕瑞昔布钠组VAS评分低，哌替啶使用率低（4.00%）（P<0.05）；两组恶心呕吐率差异无显著意义。［结论］甲状腺手术患者麻醉诱导前经静脉给予帕瑞昔布钠40 mg，可有效降低甲状腺手术患者术后的疼痛强度。

Abstract:

［Objective］To observe and evaluate the effect of preemptive analgesia with parecoxib on postoperative pain in thyroid surgery.［Methods］Three hundred ASA Ⅰ or Ⅱ patients of both sexes aged 18～65 yr with body mass index 17～29 kg/m2 were randomized into two groups,parecoxib group (n=150) and normal saline group (n=150) as control.Five minutes before the induction of anesthesia,40 mg parecoxib was given in parecoxib group.VAS was used to measured pain intensity and recorded at 0,2,6,12 and 24 h after operation.Usage of pethidine,nausea, vomiting and patient′s satisfaction were monitored.［Results］Compared with control group,VAS scores were lower,the level of patient′s satisfaction was higher,and pethidine was used less in parecoxib group (4.00%,P< 0.05).There was no difference in nausea and vomiting between groups.［Conclusion］Parecoxib 40 mg given before induction of anesthesia can improve preemptive analgesia.