卵磷脂对妊娠期高血压疾病高风险孕妇血浆前列环素、血栓素水平的影响

Impacts of lecithin on the concentration of 6-keto-PGF1α and TXB2 in pregnancy MP predicting positive HDIP

关键词:  妊娠期高血压疾病高风险  卵磷脂  前列环素  血栓素

Key words:  The high risk of hypertension disorders in pregnancy  lecithin  6-keto-PGF1α  TXB2

摘要:

［目的］探讨妊娠期高血压疾病高风险孕妇摄取卵磷脂对其血浆前列环素（PGI2）代谢产物（6-keto-PGF1α），血栓素（TXA2）代谢产物（TXB2）水平的影响及改善妊娠结局的可能性。 ［方法］选取既往无高血压、无心、肝、肾疾病单胎孕妇于妊娠20～22周应用SD-Ⅱ型妊娠期高血压预测分析系统进行预测，检测出妊娠期高血压疾病高风险（阳性）204例，从中随机选取102例作为实验组，余102例作为对照组，实验组每日口服卵磷脂2 g ，两组均进行饮食调节，运动干预，两组分别于实验前（妊娠20～22周）、实验后（妊娠36～40周）测定血浆前列环素、血栓素水平，统计并比较两组妊娠期高血压、子痫前期、子痫、胎盘早剥发生率等妊娠结局。［结果］妊娠36～40周，实验组TXB2浓度明显降低，6-Keto-PGF1α浓度明显升高,与对照组相比差异有显著性意义 （P<0.05）；实验组TXB2/6-keto-PGF1α明显低于对照组，差异有显著性意义（P<0.05 ）。实验组妊娠期高血压、子痫前期、子痫、胎盘早剥发生率低于对照组，差异有显著性意义（P<0.05）。［结论］妊娠期高血压疾病高风险孕妇者摄入卵磷脂，对降低妊娠期高血压疾病发病率，改善母儿结局有一定作用。

Abstract:

［Objective］To study the effect of soybean lecithin on the concentration of 6-keto-PGF1α and TXB2 in pregnancy SD-Ⅱ predicting positive HDIP and then improve the outcome of both mother and fetus. ［Methods］Two hundred and four pregnant women who had only one fetus, and without hypertension and disease in heart, liver and kidney, were analyzed with SD-Ⅱ predicting HDIP positive at the 20th～22nd week of their pregnancy. They were divided into 2 groups equally. The experimental group took 2 g soybean lecithin every day until the 36th～40th week, Their 6-keto-PGF1α, TXB2, levels were measured. We calculated and compared the incidents of gestational hypertension, preeclampsia, eclampsia and placental abruption in two groups. ［Results］At the 36th～40th week, The concentration of TXB2 in experimental group was significantly lower than that of control group (P<0.05). The concentration of 6-keto-PGF1α in experimental group was significantly higher than that of control group (P<0.05). The rate of TXB2/6-keto-PGF1α in experimental group was significantly lower than that of control group (P<0.05). ［Conclution］Uptaking soybean lecithin may reduce the incident of HDIP and improve the outcome of both mother and fetus obviously.