| 摘要: |
| 新生毛细血管的形成，对喉癌肿瘤细胞本身的增殖和生长是必不可少的,同时也是肿瘤侵袭、转移的必要条件。在肿瘤血管形成的机制中血管生成调节因子起着关键作用，这些因子能够控制血管生成发生、发展以及终止过程，并作为抗血管生成治疗的分子靶点受到关注。本文综述了比较重要的几种细胞活性因子：血管内皮生长因子（VEGF）、基质金属蛋白酶（MMP）、整合素、血管生成素等在喉癌血管生成方面的临床意义。 |
| 关键词: 血管生成 喉癌 细胞因子 |
| DOI：10.11724/jdmu.2011.01.21 |
| 分类号:R739.65 |
| 基金项目: |
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| Research progress of angiogenesis in invasion and metastasis of laryngeal carcinoma |
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WANG Shu-ying1, Lü Mei2, DU Cui-ping2, WU Li-hua2, YAO Yi-wen2
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1.Department of Otolaryngology,the Sixth People Hospital of Dalian,Dalian 116001,China;2.Department of Otolaryngology,the First Affiliated Hospital of Dalian Medical University,Dalian 116011,China
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| Abstract: |
| Angiogenesis is necessary for the cellular proliferation and growth of laryngeal carcinoma and is essential for tumor invasion and metastasis.Angiogenic regulatory factors play important roles in the mechanism of tumor neovascularization,controlling the development and termination of angiogenic progress.So they became the main targets for antiangiogenic therapies.We reviewed several representative cytokines regarding their clinical significance in laryngeal carcinoma,such as vascular endothelial growth factor (VEGF),matrix metalloproteinase (MMPs),integrin and angiogenin |
| Key words: angiogenesis laryngeal carcinoma cytokine |
