| 摘要: |
| ［目的］探讨P2Y2受体在涎腺腺样囊性癌（salivary adenoid cystic carcinoma，SACC）中表达的临床意义。［方法］应用免疫组织化学方法检测P2Y2受体在49例SACC和肿瘤周边涎腺组织中的表达及分布，利用显微镜图像分析技术测定P2Y2受体表达的平均灰度值，统计学分析两组该受体表达量的差异。［结果］SACC中P2Y2受体表达的平均灰度值为12.73±7.59，显著高于肿瘤周边涎腺组织的3.76±1.82（P<0.05）。SACC实性型的表达平均灰度值高于腺样-管状型，Ⅲ～Ⅳ期高于Ⅰ～Ⅱ期，神经侵袭型高于非神经侵袭型，以上分组中两组间差异均具有统计学意义。［结论］SACC中P2Y2受体表达与肿瘤的恶性程度呈正相关性。 |
| 关键词: 涎腺肿瘤 腺样囊性癌 P2Y2受体 ATP 免疫组织化学 |
| DOI：10.11724/jdmu.2011.01.04 |
| 分类号:R730.2 |
| 基金项目: |
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| Expression of P2Y2 purinoceptor in human salivary gland and adenoid cystic carcinoma |
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GAO Lu1, CHAI Song-ling1, ZHANG Fu-yin2
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1.Department of Stomatology,Dalian Medical University,Dalian 116044,China;2.Department of Stomatology,the First Affiliated Hospital of Dalian Medical University,Dalian 116044,China
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| Abstract: |
| ［Objective］To study and investigated the clinical significance of P2Y2 in salivary adenoid cystic carcinoma (SACC).［Methods］The expression and distribution of P2Y2 in 49 SACC and their surrounding salivary tissues were examined with immunohistochemistry,then the gray-scale degree of P2Y2 was measured by microscopic analyzing technique.［Results］The average gray scale of P2Y2 in the 49 SACC specimens being 12.73±7.59 was significantly higher than that of surrounding salivary tissues being 3.76±1.82 (P<0.05).In the SACC,the average scales of P2Y2 in the solid type, Ⅲ～Ⅳ stage and nerve invaded groups were significantly higher than those in the adenoid-tubular type,Ⅰ～Ⅱ stage and non-nerve invaded groups,respectively (P<0.05).［Conclusion］The expression of P2Y2 is positively correlated to malignancy of SACC. |
| Key words: salivary adenoid cystic carcinoma purinoceptor P2Y2 ATP immunohistochemistry |
