替米沙坦治疗肾性高血压的动态血压变化特点

Study of characteristics of ambulatory blood pressure in Telmisartan treated renal hypertension

关键词:  替米沙坦  肾性高血压  动态血压

Key words:  telmisartan  renal hypertension  ambulatory blood pressure

摘要:

［目的］利用动态血压评价替米沙坦治疗轻中度肾性高血压的效果。［方法］采用自身对照的方法，对89例轻中度肾性高血压患者，口服替米沙坦80 mg，1次/d，疗程4周，于治疗前后进行24 h动态血压监测，并对治疗前后的24 h、日间、夜间血压平均值、血压负荷值、血压变异性和血压昼夜节律性进行统计分析。［结果］用药后患者24 h、日间、夜间SBP和DBP的血压平均值、血压负荷值、血压变异性与用药前比较差异均有显著性意义（P<0.01），SBP、DBP夜间下降率用药后大于用药前［（10±9）%比（2±8）%，（8±10）%比（3±13）%］差异有显著性意义（P<0.01或<0.05）。［结论］替米沙坦治疗轻中度肾性高血压有效、平稳并能恢复血压昼夜节律性。

Abstract:

［Objective］To evaluate the effect of telmisartan in mild and moderate renal hypertension by ambulatory blood pressure.［Methods］Eight-nine patients with mild to moderate renal hypertension were treated with 80 mg telmisartan once a day for 4 weeks. Twenty-four hour ambulatory blood pressure was monitored before and after telmisartan taken. Average blood pressure of 24 h, daytime, night-time, blood pressure load, blood pressure variability and circadian rhythm of blood pressure.［Results］After 4 weeks of telmisartan treatment, average SBP and DBP of 24 h, daytime, night-time, blood pressure load values, blood pressure variability were significant different from those in pre-treatment (P<0.01). Night-time decline rate of SBP, DBP after treatment were statistically significant (P<0.01 or <0.05) more than that before treatment ［(10±9)% vs (2±8)% and (8±10)% vs (3±13)%］.［Conclusion］Telmisartan in patients with mild to moderate renal hypertension is effective, smooth and can restore blood pressure circadian rhythm.