心脏型脂肪酸结合蛋白在早期急性心肌梗死诊断中的价值

Significance of heart-type fatty acid binding protein in diagnosis of early acute myocardial infarction

关键词:  脂肪酸结合蛋白  急性心肌梗塞  早期诊断

Key words:  fatty acid—binding protein  acute myocardial infarction  diagnosis of early stage

摘要:

［目的］ 研究血浆心型脂肪酸结合蛋白（H-FABP）在早期急性心肌梗死（AMI）诊断中的价值。［方法］ 选择2008年5月～2008年12月因胸痛就诊于大连医科大学附属第一医院，被确诊为急性心肌梗死的患者为对象，共收集27例，选择正常对照50名，为体检健康者。采用免疫胶体金渗透方法定性检测正常对照和急性心梗患者发病3 h内血浆的H-FABP，并与心肌肌钙蛋白I （cTnI）、肌酸激酶同工酶质量（MMB）和肌酸激酶（CK）的检测结果进行比较。［结果］ H-FABP在急性心梗病人发病3 h内诊断早期AMI 的阳性率（96%）明显高于cTnI（68%）、MMB（23%）和CK（24%）（P<0.05）。［结论］ H-FABP 对于诊断早期AMI 具有较高的敏感性和良好的特异性，其对早期急性心肌梗死的诊断敏感性优于cTnI、MMB、CK。

Abstract:

［Objective］ To study the value of heart-type fatty acid binding protein (H-FABP) in the diagnosis of early acute myocardial infarction (AMI) . ［Method］ The plasma level of H-FABP was measured by sandwich ELISA in 27 patients with suspected AMI at admission within 3 hours after onset of chest pain and 50 normal healthy subjects. The plasma rations of cardiac troponin-I (cTnI), the quality of creatine kinase isoenzyme-MMB and creation phospholinase (CK) were assayed at the same time by using automatic biochemical analyzer. ［Result］ The diagnostic positive rate (96%) of H-FABP for AMI within 3 hours after onset of chest pain, was significantly higher than that of cTnI(68%), MMB(23%), CK(24%) (P<0.05). ［Conclusion］ H-FABP seems to be a useful biochemical cardiac marker for AMI in the early stage.