| 摘要: |
| ［目的］了解鼻息肉患者与人类白细胞Ⅱ类抗原（HLA-Ⅱ）的相关性。［方法］实验组为临床上已确诊的鼻息肉患者30例，对照组为81例正常健康人。采用HLA基因分型技术PCR-SSP法（PCR-sequence specific primers）检测HLA-Ⅱ类抗原。［结果］实验检测了111例的HLA-DR和HLA- DQ 共18个等位基因点，实验组和对照组之间HLA-DR16和HLA-DQ8，9 的等位基因抗原频率差异有显著性意义，其中HLA-DR16的抗原频率实验组为10.00%，对照组为1.24%，相对危险度RR=8.90，P=0.03；而HLA-DQ 8的抗原频率实验组为20.00%，对照组为4.94%，相对危险度RR=4.81，P=0.01；HLA-DQ9的抗原频率实验组40.00%，对照组12.35%，相对危险度RR=4.73，P=0.001。［结论］HLA-DR16和HLA-DQ8，9与鼻息肉的发病有关，为鼻息肉的易感基因（阳性基因）。 |
| 关键词: 鼻息肉 基因 HLA-Ⅱ类抗原 聚合酶链反应 |
| DOI：10.11724/jdmu.2009.06.12 |
| 分类号:R765 |
| 基金项目: |
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| Investigation of relation of nasal polyps with HLA-DR and DQ |
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ZHAI Li-jie1, LIU Hui2
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1.Department of Otolaryngology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China;2.Department of Clinical Immunology, Dalian Medical University, Dalian 116044, China
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| Abstract: |
| ［Objective］ The study is to search the relation between HLA-II antigens and Nasal Polyps (NP).［Methods］ Polymorphism at loci HLA-DR and HLA-DQ were examined in 30 patients with NPs and 81 healthy subjects by use of the polymerase chain reaction-sequence specific primer method.［Results］ HLA-DR16, HLA-DQ8 and HLA-DQ9 were found to be significantly associated with NPs.HLA-DR16, HLA-DQ8 and HLA-DQ9 specificities were found at higher frequencies in patients with NPs than that in healthy subjects (10% versus 1.24%, RR=8.90, P=0.3; 20.00% versus 4.94%, RR=4.81, P=0.01; and 40.00% versus 12.35%, RR=4.73, P=0.001; respectively).［Conclusion］ HLA-DR16, HLA-DQ8 and HLA-DQ9 represent potential susceptibility determinants. |
| Key words: nasal polyps gene human leukocyte antigen polymerase chain reaction |
