| 摘要: |
| ［目的］ 探讨子宫颈癌hMSH2、PCNA及P53蛋白表达的状况和意义。 ［方法］ 用免疫组织化学SP法检测54例子宫颈癌的hMSH2、PCNA及P53蛋白表达。 ［结果］ 子宫颈癌组织hMSH2、PCNA及P53蛋白表达阳性率为62.96%（34/54）、75.93%（41/54）及66.67%（36/54）；在hMSH2阳性表达和阴性表达的子宫颈癌病例PCNA阳性表达率为85.29%（29/34）和60.00%（12/20），P53阳性表达率为76.47%（26/34）和50.00%（10/20）。hMSH2与PCNA、hMSH2与P53表达呈正相关（P<0.05）。 ［结论］ hMSH2可能通过与PCNA、P53蛋白相互作用参与子宫颈癌的发生。 |
| 关键词: 子宫颈癌 hMSH2 PCNA P53 免疫组织化学 |
| DOI：10.11724/jdmu.2009.04.08 |
| 分类号:R202，R735 |
| 基金项目: |
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| Expressions of hMSH2，PCNA and P53 in cervical cancers and its significance |
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SU Hong1, LI Mei2, WANG Xiu-ying3, Lü Shen2
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1.Department of Gynaecology and Obstetrics,the Second Affiliated Hospital, Dalian Medical University, Dalian 116027, China;2.Central Laboratory, the Second Affiliated Hospital of Dalian Medical University, Dalian 116027, China;3.Department of Gynaecology and Obstetrics, Dalian Maternity Hospital, Dalian 116021, China
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| Abstract: |
| ［Objective］ To analyze the relationship of hMSH2、PCNA and P53 protein expression in cervical cancers and its significance.［Methods］ Immunohistochemistry was used to examine the proteins expression of hMSH2、PCNA and P53 in 54 cases of cervical cancers.［Results］ In cervical cancer, the positive expression rates of hMSH2, PCNA and P53 protein were 62.96%(34/54), 75.93%(41/54) and 66.67%(36/54). In the cervical cancer cases with and without hMSH2 expression, the positive expression rates of PCNA were 85.29% and 60.00%; the rates of P53 were 76.47% and 50.00%. hMSH2 and PCNA/hMSH2 and P53 protein expression were positively correlated (P<0.05).［Conclusions］ Interaction of hMSH2 to PCNA and P53 may be the carcinogenesis of cervical cancer. |
| Key words: cervical cancer hMSH2 PCNA P53 immunohistochemistry |
