正交试验优选姜油树脂凝胶的处方

Optimization of preparation formulation of ginger oleoresin gel by orthogonal test

关键词:  姜油树脂凝胶  正交试验  处方优化

Key words:  ginger oleoresin gel  orthogonal test  formulation optimize

摘要:

［目的］ 根据姜油树脂的物理化学特性，研制适合临床应用的稳定的姜油树脂制剂的处方。［方法］ 采用正交设计试验考察卡波姆-940的用量，甘油浓度以及吐温-80浓度对姜油树脂凝胶的外观和稳定性的影响。［结果］ 姜油树脂凝胶剂处方的最佳组合为：1 g/100 mL的卡波姆-940，5%的甘油，3%的吐温-80，其制成的制剂质地均匀，细腻，黏度适中，涂展性好；4000 r/min离心60 min，稳定，无分层现象。［结论］姜油树脂凝胶剂稳定性良好,该处方合理可用。

Abstract:

［Objective］ This work develops a stable prescription of ginger oleoresin gel which is suitable for clinical application according to its physical-chemistry characteristics. ［Methods］ Orthogonal experimental design was used to investigate the influence of carbomer-940 dosage, glycerol and tween-80 concentrations to appearance and stability of ginger oleoresin. ［Results］ Optimized combination for the prescription of ginger oleoresin gel was carbomer-940 (1 g/100 mL), glycerol (5%) and tween-80 (3%). Such preparation had uniform texture, moderate viscosity and good malleability. Under centrifugation (4000 r/min, 60 min), It was stable with no stratification phenomenon. Its appearance and malleability at room temperature did not change for 3 months. ［Conclusion］ The ginger oleoresin gel described in the present study has good stability and the formulation is rational and practicable.