| 摘要: |
| ［目的］ 探讨基质金属蛋白酶MMP-2和MMP-9在乳腺癌中表达及与淋巴结转移的关系。［方法］ 应用免疫组化SP方法检测乳腺癌组织88例（淋巴结转移54例，无淋巴结转移34例）和53例乳腺良性病变组织中MMP-2和MMP-9表达水平。［结果］ MMP-2和MMP-9在88例乳腺癌组织中，阳性表达率分别为78.4% （69/88）和61.4% （54/88），在乳腺良性病变组织中的阳性表达率分别为39.6%（21/53）和28.3%（15/53），两者比较，差异有显著性意义（P<0.01）；淋巴结转移组MMP-2和MMP-9的阳性表达率分别为90.7%（49/54）和74.1%（40/54），明显高于无淋巴结转移组的58.8%（20/34）和50.0%（17/34）（P<0.01）。［结论］ MMP-2和MMP-9的表达与乳腺癌淋巴结转移密切相关，可作为判断乳腺癌转移和预后的指标。 |
| 关键词: 乳腺癌 MMP-2 MMP-9 免疫组织化学 转移 |
| DOI：10.11724/jdmu.2009.03.20 |
| 分类号:R737.9 |
| 基金项目: |
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| Expression of MMP2 and MMP9 in breast cancer and its clinical significances |
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CUI -yong1, LI Hong-yuan2, WANG He-ling1, LIU Jin-gang1
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1.Department of Second Microinvasive Biliary Surgery, Affiliated Shengjing Hospital of China Medical University, Shenyang 110004, China;2.Department of General Surgery, Dalian Municiple Friendship Hospital, Dalian 116001, China
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| Abstract: |
| ［Objecitve］ To investigate the expression and prognostic significance of matrix metaloporteinase 2 (MMP-2) and matrix metaloporteinase 9 (MMP-9) in the breast cancer. ［Method］ MMP-2 and MMP-9 were detected by SP immunchistochemical technique in 88 patients with breast cancer including 54 cases with lymphnode metastasis and 34 cases without and 53 cases of breast benign disease. ［Results］ The expression rates of MMP-2 and MMP-9 were 78.4%(69/88) and 61.4% (54/88) in the breast cancers were significantly higher than those in breast benign disease which being 39.6%(21/53) and 28.3% (15/53)(P<0.01). In addition,compared with expression rate of MMP-2 and MMP-9 were 58.8%(20/34) and 50.0%(17/34),in case without lymphnode metastasis, the expression rates being 90.7%(49/54) and 74.1%(40/54) in those with lymphnode metastasis were increasing (P<0.01).［Conclusion］ The expressions of MMP-2 and MMP-9 closely correlated to lymphnode metastasis, and act as prognostic markers for patients with breast cancer. |
| Key words: breast cancer MMP-2 MMP-9 immunohistochemistry metastasis |
