| 摘要: |
| ［目的］ 探讨当归多糖激发免疫反应的特点。［方法］ 分别给予昆明种小鼠当归多糖、可溶性淀粉多糖和伤寒多糖抗原刺激，检测小鼠血清中的相应抗体及交叉抗体。［结果］ 多糖抗原均能刺激机体产生相应的IgG类抗体（当归多糖A值0.210±0.059，淀粉多糖0.809±0.423，伤寒多糖1.052±0.506）与对照相比均具有统计学意义（P<0.001）；也能在一定程度上激发非特异性IgG 类抗体既交叉抗体的产生（当归多糖免疫血清与乙型肝炎表面抗原产生交叉反应0.070±0.010），与对照组比较差异有显著性意义（P<0.001）；但不激发病理性抗体产生（RF阴性）。［结论］ 当归多糖激发免疫反应与其他多糖可能有共同的途径和机制。 |
| 关键词: 多糖 当归 免疫调节 |
| DOI：10.11724/jdmu.2009.03.07 |
| 分类号:R285.5，R392 |
| 基金项目: |
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| Features of immune response activated by Angelica polysaccharides |
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SUN Wen-ping1, LUO-Hong1, YANG-Guang1, GAO Xiao-ping2, LIU Hui1
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1.Department of Clinical Immunology and Microbiology, Dalian Medical University, Dalian 116044, China;2.Department of Laboratory, the Second Affiliated Hospital of Dalian Medical University, Dalian 116027, China
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| Abstract: |
| ［Objective］ This study explores the features of immune response activated by Angelica polysaccharides. ［Methods］ The KM mice were immuned with Angelica polysaccharides, starch polysaccharides and Bacillus typhi polysaccharides respectively. Then the corresponding antibody and cross-reactive antibodies in the serum of the mice were detected. ［Results］ Specific and nonspecific IgG was produced after the polysaccharide immunizations, (A of Angelica polysaccharides is 0.210±0.059,starch polysaccharides 0.089±0.423,Bacillus typhi polysaccharides 1.05±0.506,P<0.001) but pathological antibodies could not be prompted. ［Conclusion］ It may be identical mechanism for Angelica polysaccharides and other polysaccharides to stimulate immune system to response. |
| Key words: polysaccharides Angelica immunoregulation |
