| 摘要: |
| 巨噬细胞集落刺激因子（M-CSF）是一种具有谱系特异性的细胞因子，是目前临床上应用最广泛的细胞因子之一。M-CSF可诱导破骨细胞分化增殖，维持其活性，并可抑制破骨细胞凋亡。其在治疗骨骼石化症及体外诱导破骨细胞分化等方面也有广泛引用。本文着重概述了M-CSF对破骨细胞的生物作用。 |
| 关键词: 巨噬细胞集落刺激因子 破骨细胞 骨代谢 |
| DOI：10.11724/jdmu.2009.02.31 |
| 分类号:Q593 |
| 基金项目: |
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| Current progress of biological role of macrophage colony-stimulating factor on activity of osteoclasts |
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GUO Li-jia, CHANG Xin
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Department of Stomatology, the Second Affiliated Hospital of Dalian Medical University, Dalian 116027, China
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| Abstract: |
| Macrophage colony-stimulating factor (M-CSF), a lineage-specific cytokine, is one of the most comprehensive factors for clinical use. M-CSF can induce human osteoclast formation and stimulate them to differentiate and survive. It also can inhibit the apoptosis of osteoclasts. M-CSF is also widely used in the treatment of osteopetrosis and osteoclasts culture in vitro. This article reviews the current progress of the biological role of M-CSF on the activity of osteoclasts. |
| Key words: macrophage colony-stimulating factor osteoclast bone metabolism |
