| 摘要: |
| ［目的］ 应用ROC曲线探讨鳞状细胞癌抗原（squamous cell carcinoma antigen, SCC-Ag）在宫颈鳞癌的诊断意义。 ［方法］ 对31例宫颈鳞状细胞癌患者、33例非宫颈鳞状细胞癌患者、30例正常健康的妇女，采用ELISA方法检测血清中SCC-Ag的含量。建立ROC曲线评价系统。
［结果］ 宫颈鳞癌组SCC-Ag测得值的中位数为2.80 μg/L，非宫颈鳞癌组SCC-Ag测得值的中位数为0.51 μg/L，正常对照组SCC-Ag测得值均数为0.34 μg/L。宫颈鳞癌组与非宫颈鳞癌组、正常对照组比较，差异具有统计学意义（P<0.05）。应用ROC曲线分析，曲线下面积为0.853，95%可信区间为0.755~0.950。最佳临界值为1.06 μg/L ，其灵敏度为74.2%，特异度为90.3%。 ［结论］ 鳞状细胞癌抗原是宫颈鳞癌较特异的肿瘤标志物，可作为宫颈鳞癌的辅助诊断指标。 |
| 关键词: 鳞状细胞 宫颈癌 诊断 |
| DOI：10.11724/jdmu.2009.02.27 |
| 分类号:R446 |
| 基金项目: |
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| Diagnostic significance of SCC-Ag in cervical squamous cell carcinoma by ROC curve analysis |
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ZHU Hong, WANG Xu, XU Yu-hai, FAN Cun-lin, WANG Nan
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Department of Clinical Laboratory, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China
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| Abstract: |
| ［Objective］ This study is to investigate the diagnostic value of SCC-Ag as a tumor marker in the cervical squamous cell carcinoma using ROC curve analysis. ［Methods］ SCC-Ag was examined by ELISA in 31 patients with cervical squamous cell carcinoma, 33 patients with non-cervical squamous cell carcinoma, and 30 healthy women. ROC curve was established based on the examination. ［Results］ The median of SCC-Ag level in the cervical squamous cell carcinoma was 2.80 μg/L, which was higher (P<0.05) than that in non-cervical squamous cell carcinoma (0.51 μg/L) and control groups (0.34 μg/L). According to ROC curve, the area under the ROC curve (AUC) was 0.853 and the 95% confidence interval of the area under the curve was 0.755 to 0.950. The cut off value of SCC-Ag was 1.06 μg/L. The sensitivity was 74.2% and the specificity was 90.3%. ［Conclusion］ ROC curve analysis shows that SCC-Ag is excellent tumor marker that is very useful for the diagnosis of the cervical squamous cell carcinoma. |
| Key words: squamous cell cervical carcinoma diagnosis |
