可逆性后部脑白质脑病综合征的临床及影像学特征

Clinical and imaging characteristics of Reversible posterior leukoencephalopathy syndrome

关键词:  可逆性后部脑白质脑病综合征  临床  影像学

Key words:  reversible posterior leukoencephalopathy syndrome( RPLS)  clinical  imaging

摘要:

［目的］探讨可逆性后部脑白质脑病综合征（reversible posterior leukoencephalopathy syndrome，RPLS）的临床及影像学表现，以提高其早期诊断能力。［方法］回顾性分析5例RPLS患者的临床及影像学资料。［结果］5例均有突发的血压增高、头痛、癫痫，4例有视觉障碍，1例出现共济失调。CT显示为双侧顶枕叶白质为主的低密度影，同时伴有小脑、脑干受累的2例；MR显示为双侧顶枕叶白质为主的长T1长T2异常信号，FRAIL呈高信号。［结论］突发的血压增高、头痛、视觉障碍和癫痫是其主要临床特点，影像学特征主要为大脑后部脑白质的长T1长T2信号，FRAIL呈高信号。

Abstract:

［Objective］To investigate the clinical and imaging characteristics of Reversible posterior leukoencephalopathy syndrome( RPLS), sharpens its early diagnosis ability.［Methods］The clinical and imaging date of 5 patients with RPLS were analyzed retrospectively.［Results］All the cases presented with a sharp-edged rise of blood pressure, the headache and seizure, 4 with disturbance of vision, 1 with ataxia. CT demonstrated two-sided goes against the occipital lobe white matter priarily low density shade,cerebellar in 2,brain stem in 2. MRI of head mainly showed white brain abnormalities(in most cases bilaterally symmetric) in the posterior regions of the brain.［Conclusion］The sharp-edged rise of blood pressure,headache, disturbance of vision and epilepsy are the principal clinical symptom in RPLS.the imaging characteristics of RPLS are symmetrical long T1 the long T2 signal on the bilaterior white matters of cerebrum, high signal in FLAIR.