孤立性纤维瘤3例及文献复习

Solitary fibrous tumors: 3 case reports and literature review

关键词:  孤立性纤维瘤  组织病理学  诊断

Key words:  solitary fibrous tumor  histopathology  diagnosis

摘要:

［目的］ 探讨孤立性纤维瘤（SFT）的临床病理特征。［方法］对3例SFT的临床表现、组织形态和免疫表型进行研究和随访，并复习文献。［结果］肿瘤主要由梭形细胞组成，瘤细胞排列疏密不等，可见血管外皮瘤样排列方式。梭形细胞表达Vimentin、CD34和bcl-2，不表达Cytokeratin （Pan）、SMA、CD117及S-100。随访1~5年，无复发和转移。［结论］孤立性纤维瘤是一种少见的、大多数病例临床上呈良性经过、偶有复发和转移的中间型肿瘤，需与间皮瘤、血管外皮瘤、神经纤维瘤等鉴别。

Abstract:

［Objective］To investigate the clinicopathologic characteristics of solitary fibrous tumors.［Methods］The clinical features, pathologic patterns and immunophenotype were analysed for three cases of SFTs.［Results］Histologically, SFT was composed of bland spindle cell, typically arranged in haemangiopericytoma-like pattern. Positive immunoreactivity for vimentin, CD34 and bcl-2, negative for Cytokeratin(Pan),SMA,CD117 and S-100.［Conclusion］SFT is a rare tumor, differential diagnosis should be made with mesothelioma, hemangiopericytoma neurofibroma and others.