复合乳化剂对微乳成乳区域的影响

Effect of compound surfactants on O/W microemulsion region

关键词:  复合乳化剂  三元相图  微乳

Key words:  compound surfactants  pseud-triangular phase diagrams  microemulsion

摘要:

［目的］研究复合乳化剂对O/W微乳成乳区域的影响，为微乳的处方筛选提供依据。［方法］选用磷脂（PC）和泊洛沙姆188（F68）为复合乳化剂，甘油为助乳化剂，分别选取不同的乳化剂/助乳化剂（Km值）和F68/PC的不同比例绘制三元相图；对比相同条件下以磷脂为乳化剂，甘油为助乳化剂, 油酸乙酯为油相所得相图的微乳区域面积，考察复合乳化剂对O/W微乳成乳区域的影响。［结果］以磷脂和F68为复合乳化剂的三元相图的成乳区域较单乳化剂的成乳区域明显增大。当Km=1∶1，成乳区域较大，在实验取值范围内随着Km的增大或减小微乳区域随之减小，随着复合乳化剂中F68的比例的增大，微乳区域随之变大。当Km=1∶1且F68∶PC=2∶1时，所得的成乳区域最大。［结论］较单乳化剂复合乳化剂可显著增大O/W微乳的成乳区域，对于寻找可形成稳定O/W微乳的处方有积极的意义。

Abstract:

［Objective］To study the effect of compound surfactants on the O/W microemulsion(ME)region,which was guidance for selection the formulation of ME.［Methods］Phospholipid (PC)and Poloxamers 188(F68) were used as compoundsurfactants ,glycerol as cosurfactant,ethyl oleate as oil phase. Prepare the pseud-triangularphase diagrams with different ratio of surfactant/cosurfactant(Km) and F68/PC.Whilefor the PC,glycerol and ethyl oleate system with the same condition.Then,the correspondingarea of O/W ME in both system were compared .The effect of compound surfactantson the O/W ME region was investigated.［Results］The micromulsion region of compound surfactants system was larger than the single surfactant system. In the scope of this study ,thearea of ME region was decrease when the Km>1 or Km<1 , while the area of ME was increase with the increase of the ratio of F68.［Conclusions］The microemulsion region of compound surfactants system is more larger than the single surfactant system.The afflication of compound surfactants is a feasible method with guiding significance for the selection of ME formulation.