COPD合并肺心病急性加重期患者红细胞、单个核细胞及多形核粒细胞钾、钠含量的变化

Potassium and sodium content of monocuclear and polynuclear blood cells and red blood cells in COPD patients with chronic cor pulmonale

关键词:  COPD  肺心病  钾  钠

Key words:  COPD  cor pulmonale  potassium  sodium

摘要:

［目的］了解慢性阻塞性肺疾病（COPD）合并肺心病急性加重期患者红细胞、单个核细胞及多形核粒细胞内钾（K）、钠（Na）含量的变化。［方法］选取住院COPD合并肺心病患者40例，健康对照组36例。采用密度-梯度法分离血细胞，以原子吸收分光光度计测定细胞的K、Na含量。 ［结果］患者组红细胞K（65.97±12.80）mmol/L、Na（7.93±1.33）mmol/L明显降低（P<0.05），单个核粒细胞K（11.93±3.34）μmol/10⁹cells、Na（27.32±18.76）μmol/10⁹cells无明显改变（P>0.05），多形核粒细胞K（27.32±18.76）μmol/10⁹cells、Na（15.84±12.53）μmol/10⁹cells，高于对照组，差异有显著性意义（P<0.05）。单个核细胞K与多形核粒细胞K、Na及PaCO₂呈正相关（相关系数分别为0.567，0.34，0.31，P<0.05）。［结论］COPD合并肺心病患者存在体K的缺失，多形核粒细胞及单个核粒细胞并不能很好地反映体内K、Na的慢性改变。

Abstract:

［Objective］To investigate potassium and sodium content of red blood cells, mononuclear and polynuclear blood cells in COPD patients with chronic cor pulmonale.［Methods］Mononuclear and polynuclear blood cells was separated by density-gradient centrifugation. Potassium and sodium content was analyzed by atomic absorption spectrometer.［Results］Potassium (65.97±12.80) mmol/L and sodium (7.93±1.33) mmol/L content of red blood cells decreased significantly in patients (P<0.05), while potassium(11.93±3.34) μmol/109cells and sodium (27.32±18.76) μmol/10⁹cells in mononuclear blood cells remained unchanged (P>0.05). Potassium ( 27.32±18.76) μmol/10⁹cells and sodium (15.84±12.53)μmol/10⁹cells content in polynuclear blood cells increased significantly (P<0.05). Potassium content in mononuclear blood cells has a positive correlation with potassium and sodium content of polynuclear blood cells and PaCO₂ (correlation coefficient was 0.567,0.34,and 0.31,respectively. P<0.05)［Conclusions］There is potassium deficiency in COPD patients with chronic cor pulmonale. Potassium and sodium in mononuclear and polynuclear blood cells may not be a good index of intracellular potassium and sodium.