40例骨肉瘤的临床疗效分析

Effectiveness of osteosarcoma(report of 40 cases)

关键词:  骨肉瘤  保肢术  新辅助化疗。

Key words:  osteosarcoma  limb salvage  neoadjuvant　chemotherapy

摘要:

［目的］探讨如何提高骨肉瘤患者的5年生存率。［方法］ 通过术后5年以上跟踪随访，分析40例骨肉瘤患者的病理类型，临床分期，手术方式，放化疗情况。［结果］ 全组5年生存率为20％（8/40），手术加新辅助化疗组5年生存率60％（6/10）,手术加一般化疗组5年生存率为18％（2/11）。两组差异有显著性意义（P＜0.05）。［结论］新辅助化疗的临床应用已使得保肢手术成为骨肿瘤治疗的主要方向。与此同时，骨肉瘤的5年生存率已由原来的10%~20％提高到60%~80％。参照Eneking分期，采用规范的广泛切除术，也是提高保肢术患者5年生存率的基本条件之一。

Abstract:

［Objective］To investigate the clinical treatment of patients with osteosarcoma.［Methods］Clinicaldata of 40 patients with osteosarcoma treated were retrospectively analyzed including image examination, pathologic examination and surgical procedure.［Results］The 5 years survival rate of 40 cases of osteosarcoma were 20% (8/40). The 5 years survival rate of complete resection were 60%(6/10). The 5 years survival rate of partial resection were 18%(2/11).［Conclusion］To treat osteosarcoma through surgery combined with neoadjuvant Chemotherapy is effective and minimally invasive treatment for patients. The 5 years survival rate of osteosarcoma improves from 10%~20% to 60%~80% now. Complete resection is the key for the treatment of osteosarcoma.