MGMT表达缺失在胃癌发生中的作用

Role of MGMT absent expression in gastric carcinogenesis

关键词:  胃癌  MGMT  HP

Key words:  gastric cancer  MGMT  HP

摘要:

［目的］ 探讨DNA直接修复蛋白MGMT表达缺失在胃癌发生中的作用和意义。［方法］免疫组织化学方法检测66例胃癌、34例胃炎（慢性浅表性胃炎25例，慢性萎缩性胃炎9例）标本MGMT表达。［结果］MGMT表达率在慢性浅表性胃炎黏膜（CS）、慢性萎缩性胃炎黏膜（CA）和胃癌（GC）组分别为48.0%（12/25）、33.3%（3/9）和19.7%（13/66）（CS v.s. CA,P=0.697; CA v.s. GC, P=0.392; CS v.s. GC, P=0.007）。胃癌组，MGMT表达与患者性别、年龄、胃癌分化程度及HP感染间均无显著相关关系；胃炎组，HP感染与MGMT表达显著正相关（r=0.408,P=0.017）。［结论］MGMT表达缺失引起的胃黏膜细胞DNA损伤修复障碍可能是胃癌发生的原因之一。

Abstract:

［Objective］To explore the role and significance of MGMT absent expression in the gastric carcinogenesis.［Methods］Immunohistochemistry was used to detect MGMT expressions in 66 gastric cancer and 34 gastritis samples, (including 25 chronic superficial gastritis and 9 chronic atrophic gastritis samples).［Results］In chronic superficial gastritis, chronic atrophic gastritis and gastric cancer groups, the rates of MGMT expression were 48.0% (12/25), 33.3% (3/9) and 19.7 (13/66) respectively (CS v.s. CA, P=0.697; CA v.s. GC, P=0.392; CS v.s. GC, P=0.007); in gastric cancer group, MGMT expression was not significantly related to gender, ages of patients, differentiation of gastric cancer and infection of helicobacter pylori (HP); while in gastritis group, infection of HP was significantly related to MGMT expression (r=0.408, P=0.017).［Conclusions］MGMT absent expression can induce the accumulation of DNA damaged by methylating agents, which may be one of gastric carcinogenesis reasons.