美罗华联合CHOP方案治疗滤泡型非霍奇金氏淋巴瘤1例

A case of combined chemotherapy of CHOP with Rituximab in FL

关键词:  美罗华  化疗  滤泡型淋巴瘤

Key words:  rituximab  chemotherapy  follicular lymphoma

摘要:

［目的］ 评价美罗华联合CHOP方案治疗滤泡型NHL的临床效果及不良反应。［方法］第1天：美罗华375 mg/m²2，600 mg静点；地塞米松15 mg静推；第2天：环磷酰胺750 mg/m²，1.2 g静推;长春新碱1.4 mg/m²，2mg静推；法玛新60 mg/m²，110 mg静推;第2~5天：强的松100毫克口服。每21天1周期，连用7周期。［结果］ 完全缓解。毒副反应主要是骨髓抑制Ⅲ°、口腔炎Ⅲ°、便秘Ⅲ°、脱发Ⅱ°、恶心呕吐Ⅰ°，可耐受。［结论］美罗华联合CHOP方案治疗滤泡型NHL可获得较好疗效，毒副反应可以耐受，是一个较好的化疗方案。

Abstract:

［Objective］To evaluate the results of combined Rituximab with CHOP in the chemotherapy of follicular lymphoma.［Methods］A patient with follicular lymphoma received Rituximab 375mg/m² by intravenous infusion on the fifth day,Dexamethasone 15mg by intravenous on the first day,Cytoxan 750 mg/m² by intravenous on the second day,Vinblastine 1.4mg/m² by intravenous on the second day. Epirubicin Hydrochloride 60 mg/m² by intravenous on day2. Prednisone 100 mg by Poon the second day to the fifth day.The treatment was repeated every 21 days, up to 7 cycles.［Results］CR .The main toxicities were myelosuppression, oral inflammation，constipation，alopecia, nausea and other side effects.［Conclusions］A high response rate can be obtained in follicular lymphoma by CHOP plus Rituximab. It is a promising antitumor agent with tolerable toxicity.