hMSH2蛋白和MGMT蛋白在胃癌发病中的意义

Significance of gene product expressions of hMSH2 and MGMT in gastric carcinogenesis

关键词:  hMSH2  MGMT  胃癌

Key words:  hMSH2  MGMT  gastric carcinoma

摘要:

［目的］探讨错配修复基因hMSH2和DNA修复酶MGMT异常表达在胃癌发病中的意义。［方法］采用免疫组织化学方法检测40例胃癌组织和38例胃炎组织hMSH2和MGMT蛋白的表达情况。［结果］胃癌组的hMSH2蛋白阳性表达率为75.0%(30/40)，显著高于胃炎组的28.9%(11/38) (P<0.05)；胃癌组的MGMT蛋白阳性表达率为20.0%(8/40)，显著低于胃炎组的65.8 %(25/38) (P<0.05)。胃癌及胃炎两组中hMSH2蛋白和MGMT蛋白表达均正相关(P<0.05)。［结论］胃癌的发生可能与错配修复基因hMSH2和DNA修复酶MGMT的功能下降有关。

Abstract:

［Objective］To detect the significance of gene product abnormal expressions of hMSH2 and MGMT in gastric carcinogenesis.［Methods］Immunohistochemical technique was used to detect hMSH2 and MGMT protein expressions in 40 cases of gastric carcinomas and 38 cases of gastritis.［Results］The positive rate of hMSH2 in gastric carcinoma being 75.0%(30/40) was significantly higher than that in gastritis being 28.9 %(11/38) (P<0.05). The positive rate of MGMT in gastric carcinoma being 20.0 %(8/40) was significantly lower than that in gastritis being 65.8 %(25/38) (P<0.05). There was significantly positive correlation between the expressions of hMSH2 and MGMT proteins in both gastric carcinoma and gastritis groups. ［Conclusions］The functional degression of hMSH2 and MGMT proteins may play some roles in the gastric carcinogenesis.