胎膜早破孕妇血清中IL-8水平与绒毛膜羊膜炎的关系

Relationship between maternal serum Interleukin-8 and chorioamnionitis in patients with PROM

关键词:  胎膜早破  白细胞介素-8  绒毛膜羊膜炎

Key words:  PROM  interleukin-8  chorioamnionitis

摘要:

［目的］探讨胎膜早破孕妇血清中IL-8的含量与绒毛膜羊膜炎的关系。［方法］采用放射免疫法对45例胎膜早破和30例正常足月孕妇血清中IL-8浓度进行测定，同时胎 膜行病理检查。［结果］胎膜早破孕妇血清中IL-8的水平随破膜时间的延长而升高；胎膜早破组血清中IL-8的水平为(824.04±341.28) pg/mL，其水平明显高于对照组，两组比较，差异有统计学意义（P<0.05）；胎膜早破中绒毛膜羊膜炎患者血清中IL-8的水平为(985.50±422.15) pg/mL，其水平明显高于非绒毛膜羊膜炎患者，两组比较，差异有统计学意义（P<0.05）；轻度、中、重度绒毛膜羊膜炎组孕妇血清中IL-8的水平分别为（912.35 ±321.00）、（1568.46±789.68）、2612.67 pg/mL，与非绒膜羊膜炎组相比均有显著性差异(P<0.05)。［结论］母血中IL-8水平可作为足月胎膜早破组织绒毛膜羊膜炎的一个预测指标。

Abstract:

［Objective］To study the relationship of materal serum interleukin-8(IL-8) concentration in patients with premature rupture of me mbranes (PROM) for chorioamnionitis.［Methods］ Maternal serum IL-8 were measured by radioimmunoassay in 45 case of pregnant women with PROM and 30 case' of normal pregnant women .Chorioamnionitis was histopathologically confirmed after delivery.［Resullts］The longer the duration from rupture of membranes of delivery was,the more serious chorioamnionitis was,and the higherthe levels of IL-8 in maternal serum;The levels of IL-8 in materal serum were (824.04±341.28) pg/mL,significantly higher in patients with PROM than those of the control group (P<0.05); The levels of IL-8 in materal serum were (985.50±422.15) pg/mL, significantly higher in patients with chorioamnionitis than those of the non- chorioamnionitis (P<0.05);The serum of materal IL-8 with histological chorioamnionits showed a significantly higher than those without chorioamnitis(P<0.05), The levels of IL-8 in materal serum were（912.35±321.00）、（1568.46±789.68）、（2612.67） pg/mL.［Conclusion］Measurement of materal serum IL-8is a marker for screening histological chorioamnionits PROM .