长托宁用于心脏病人非心脏手术前用药的临床研究

Clinical research of penehyclidine hydrochloride as premedicent of general anesthesia in cardiac patient undergoing noncardiac surgery

关键词:  长托宁  东莨菪碱  术前药

Key words:  penehyclidine hydrochloride  scopolamine  premedicent

摘要:

［目的］探讨长托宁作为心脏病人非心脏手术前用药的临床效果。［方法］ ASAⅡ-Ⅲ级的病人50例，随机分为长托宁组和东莨菪碱组，免用术前药，入室后肌注长托宁0.01 mg/kg和东莨菪碱0.006 mg/kg，40 min后开始麻醉和手术。记录给药前、给药后10、20、30、40 min时的心率(HR)、血压（Bp）变化情况及观察病人镇静、口干程度。［结果］ Ⅰ组SBP在给药后30、40 min时低于给药前；DBP在20、30、40 min时较给药前低；HR在20、30 min时较给药前低，(P<0.05)。Ⅱ组SBP、DBP在给药后30 min时均较用药前高，且明显高于Ⅰ组，(P<0.05)。HR在20、30、40 min时高于给药前，且较Ⅰ组明显增快，(P<0.05)。组间比较口干与镇静程度均没有显著差异。［结论］ 长托宁作为心脏病人非心脏手术前用药较东莨菪碱效果好。

Abstract:

［Objective］ To research the effects of perehyclidine hydrochloride as premedicent in cardiac patient during noncardiac surgery. ［Methods］ Fifty patients with ASAⅡ-Ⅲ were randomly divided into two group : perehyclidine hydrochloride group,received perehyclidine hydrochloride 0.01 mg/kg im and group scopolamine ,received scopolamine 0.006 mg/kg im. HR, Bp Thirstiness and sedation were recorded on 4 time-points:before injection, 10 minutes,20 minutes,30 minutes after injection. ［Results］ Perehyclidine hydrochloride decreased blood pressure and heart rates significantly especially SBP in 30,40minutes after injection, DBP in 20, 30,40 minutes after injection and HR in 20,30minutes after injection (P<0.05). scopolamine increased blood pressure and heart rates significantly compared with perehyclidine hydrochloride especially Bp in 30minutes after injection and HR in 20,30,40minutes after injection(P<0.05). There were no significant differences in thirstiness and sedation between two groups. ［Conclusions］ Perehyclidine hydrochloride is a better choice of premedicent for cardiac patients undergoing noncardiac surgery.