低分子肝素对重度妊高征患者血浆D-D二聚体及血小板聚集功能的影响

Effect of low molecular weight heparin on plasma D-Dimer concentration and platelet aggregation rate in severe pregnancy induced hypertension

关键词:  低分子肝素  妊高征  D-D二聚体  血小板聚集率  产后出血

Key words:  LMWH,PIH,D-Dimer,platelet aggregation rate  postpartum hemorrhage

摘要:

应用低分子肝素（LMWH）结合硫酸镁治疗重度妊高征，探讨LMWH在重度妊高征治疗中的价值及可行性。［方法］选取重度妊高征患者52例，硫酸镁治疗26例（Ⅰ组），硫酸镁+LMWH治疗26例（Ⅱ组）；检测各组产妇血浆D-D二聚体水平及血小板聚集率变化；测量产后或术后2 h内出血量。［结果］Ⅱ组治疗前后D-D二聚体及血小板聚集率明显降低（P＜0.05)；Ⅰ组治疗前后血浆D-D二聚体水平及血小板聚集率变化不明显（P＞0.05）；Ⅰ、Ⅱ组产后出血量无显著性差异（P＞0.05）。［结论］传统的硫酸镁治疗对重度妊高征患者血浆D-D二聚体水平和血小板聚集率的影响不大，LMWH结合硫酸镁可显著降低D-D二聚体水平及血小板聚集率且并不增加产后及术后出血量。

Abstract:

To evaluate the effect of LMWH by using LMWH combining magnesium sulfate to therapy severe PIH. ［Methods］Clinical information of 52 patients with severe PIH,26 patients treated with magnesium sulfate (Ⅰgroup)(n=26); the others treated with magnesium sulfate and LMWH (Ⅱgroup)(n=26). Examining plasma D-Dimer and platelet aggregation rate and measure the bleeding capacity within 2 hours pastpartum or after surgery. ［Result］In groupⅡ,after treatment the plasma D-Dimer concentration and the platelet aggregation rate declined obviously, has significant differences(P<0.05). In group Ⅰ,the plasma D-Dimer concentration and platelet aggregation rate has no significant change. The bleeding capacity within 2 hours past partum or after surgery has no significant differences(P>0.05) compared with the two treatment groups. ［Conclusion］LMWH combinating magnesium sulfate treat severe PIH can reduce the plasma D-Dimer concentration and platelet aggregation rate markedly and can not increase the bleeding capacity within two hours pastpartum or after surgery.