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| CD44V6在乳腺癌中的表达及与侵袭、转移的关系 |
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陈英杰1, 刘超1, 葛凤霞2, 吕申3
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1.大连大学医学院,病理学教研室,辽宁,大连,116622;2.大连市肿瘤医院,病理科,辽宁,大连,116030;3.大连医科大学,第二临床学院,实验中心,辽宁,大连,116027
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| 摘要: |
| 探讨乳腺癌细胞CD44V6的表 达及其与侵袭、转移的关系。［方法］ 免疫组织化学方法检测60例乳腺癌患者癌组织中CD4 4V6的表达。［结果］ CD44V6的表达阳性率在中、低分化组分别为74.07%（20/27）、80.76 %（21/26），明显高于高分化组的表达阳性率42.85%（3/7）(P<0.01)；在淋巴结 转移组的表达阳性率为86.11%（31/36）明显高于非淋巴结转移组的表达阳性率54.16%(13/2 4)（P<0.01）。［结论］ 乳腺癌中CD44V6的高表达可能预示肿瘤的恶性度与高转移能力 |
| 关键词: 乳腺癌 CD44V6 免疫组织化学 转移 |
| DOI：10.11724/jdmu.2004.02.04 |
| 分类号:R737.9 |
| 基金项目: |
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| Relationship of CD44V6 expression to invasion and metastasis of breast cancer |
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CHEN Ying-jie1, LIU Chao1, GE Feng-xia2, L Shen3
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1.Department of Pathology, Dalian University Medical College, Dalian 116622, China;2.Department of Pathology, Dalian Tumor Hospital, Dalian 116030, China;3.Centre of Experiment, the Second Hospital, Dalian Medical University, Dalian 1 16023, China)
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| Abstract: |
| To study the relationship of CD44V6 e xpression to malignant behaviors of breast cancer. ［Methods］ The expressions of CD44V6 of 60 breast c ancers were detected by immunohistochemical method and the relationship between the expression and pathological factors was analyied. ［Results］ The expression r ates of CD44V6 in the groups of poor and medial differentiation being 80.76%(21/ 26) and 74.07%(20/27) were significantly higher than that group of well differen tiation being 42.85%(3/7)(P<0.01). The expression rate of CD44V6 in the grou p of lymph node metastases being 86.11%(31/36) was significantly higher than that gr oup of non-lymph node metastases being 54.16%(13/24) (P<0.01). ［Conclusions ］ The overexpression of CD44V6 may indicate potentiality of invasion and metastasis o f breast cancer |
| Key words: breast cancer CD44V6 immunohistochemistry metas tasis |