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| 线刺法蛛网膜下腔出血动物模型制备 |
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陈德森1, 郭俐宏2, 罗超1, 彭吉霞1, 郭锐1
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1.郧阳医学院,机能实验室,湖北,十堰,442000;2.太和医院,针灸科,湖北,十堰,442000
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| 摘要: |
| 线刺法建立可真实模拟蛛网膜下腔出 血(SAH)的动物模型。［方法］ 大鼠经右侧 翼腭动脉线刺法刺破Willis环的血管分叉处，造成Willis环血管破裂出血后动态观测局部脑 血流（rCBF）及脑电图(EEG)的变化。［结果］ 蛛网膜下腔出血(SAH)后rCBF及EEG幅度急 剧下降，分别下降为40.5 % 和68.6 %，30 min SAH组rCBF下降幅度最大（62.3 %）， EEG 15 min下降幅度最大（89.5 %）。rCBF下降持续48 h，颅底解剖学检查发现Willis环的血 管分叉处有陈旧性出血。［结论］ 该动物模型模拟SAH真实可靠。 |
| 关键词: 蛛网膜下腔出血 脑血流 脑电图 |
| DOI：10.11724/jdmu.2004.01.16 |
| 分类号:Q954.52 |
| 基金项目: |
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| Preparation of animal model of subarachnoid hemorrhage |
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CHEN De-sen1, GUO Li-hong2, LUO Chao1, PENG Ji-xia1, GUO Rui1
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1.Lab of Functions, Yunyang Medical College, Shiyan 442000, China;2.Department of Acupuncture, Taihe Hospital,Shiyan 442000, China)
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| Abstract: |
| To prepare the animal model of subarachnoid he morrhage(SAH). ［Methods］ The fork of Willis ring was pierce with a line throug h right pterygop alatine artery to dynamically record the change in regional cerebral blood flow( rCBF) and electroencephalograph(EEG). ［Results］ At piercing the rCBF and EFG d ropped rapidly by 40.5% and 68.6% respectively . At 30 min rCBF dropped to bott om by 62.3% and at 15 min EFG by 89.5%.the drop of rCBF lasted 48 hours. Basic rania l anatomy showed remote hemorrhage at the fork of Willis ring. ［Conclusion］ Th e model is reliable in simulating SAH. |
| Key words: subarachnoid hemorrhage cerebral blood flow elect roencephalograph |