| 引用本文: | 曹华军,戚小惠,王丽丽,王旭,韩丽霞,程艳杰,范存琳.血Cystatin C在糖尿病肾病诊断中的应用[J].大连医科大学学报,2003,25(2):. |
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| 血Cystatin C在糖尿病肾病诊断中的应用 |
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曹华军1, 戚小惠2, 王丽丽3, 王旭1, 韩丽霞1, 程艳杰1, 范存琳1
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1.大连医科大学,第一临床学院,检验科,辽宁,大连,116011;2.大连市金州区第一医院,检验科,辽宁,大连,116100;3.威士达医疗有限公司,辽宁,大连,116000
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| 摘要: |
| 探讨血半胱氨酸蛋白酶抑制剂C(Cystatin C)测定在糖尿病肾病早期诊断中的应用价值。［方法］ 49例2型糖尿病患者按白蛋白排泄率（UAE）分为无DN组19例UAE <15μg/min ；DN早期组17例UAE>15 μg/min但<200μg/min；DN组13例UAE>200μg/min。同时选取健康对照组20例，各组均测定血清中的肌酐(Cr)、尿素及Cystatin C和晨尿中的白蛋白(Alb)/尿Cr。进而对各指标的敏感性和特异性进行比较，同时对各指标和UAE的相关性进行分析。［结果］以UAE为标准，DM患者中DN的诊断敏感性和特异性，血Cr（ |
| 关键词: Cystatin C 糖尿病肾病 肌酐 白蛋白 尿素 |
| DOI：10.11724/jdmu.2003.02.24 |
| 分类号:R446.1 |
| 基金项目: |
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| Measurement of serun Cystatin C in patients with diabetic neuropathy |
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CAO Hua-jun1, QI Xiao-hu2, WANG Li-li3, WANG Xu1, HAN Li-xia1, CHENG Yan-jie1, FAN Cun-lin1
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1.Department of Clinical Laboratory,the First Affiliated Hospital of Dalian M;2.Departmat of Clinical Laboratory, the First Hospital of Jinzhou,Dalian 116600, China;3.Vastec Medical Ltd. Dalian 116000, China
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| Abstract: |
| This study evaluated serum Cystatin C as a potential new marker of glomerular filtration rate (GFR) in patients who had steady-state diabetes with early renal impairment．［Methods］ Patients 49 with Type 2 diabetes mellitus were classified into three groups according to urine albumin excretion rate (UAE) (group 1, NDN group,19 patients,UAE <15 μg/min； group 2, DN early stages group,17 patients ,UAE >15μg/min and <200μg/min; group 3, DN group, 13 patients, UAE>200 μg/min),20 healthy people were selected as control group. Serum creatinine, serum Cystatin C, serum urea, and urine albumin:creatinine ratio were measured. Sensitivity, specificity and correlation coefficients with UAE were analy |
| Key words: Cystatin C diabetic neuropathy(DN) creatinine albumin urea |