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| 细胞角蛋白19片段（CYFRA21-1）检测对肺癌临床诊断价值的研究 |
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李敬1, 戚小惠2, 蔡新霞1, 张华力1
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1.大连医科大学,第一临床学院,核医学科,辽宁,大连,116011;2.大连市金州区第一医院,检验科,116100
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| 摘要: |
| 探讨细胞角蛋白19片段（CYFRA21-1）检测在肺癌临床诊断中的价值。［方法］采用免疫放射分析法对70例肺癌患者进行CYFRA21-1含量测定，并与40例胸部良性疾病（BLD）患者，40例健康人血例健康人进行比较。［结果］肺癌患者血清CYFRA21-1含量为(4.64±3.68) ng/mL，胸部良性疾病患者为(2.19±0.80)ng/mL（P<0.01）,健康人为(1.71±0.74) ng/mL（P<0.01），肺癌患者血清 CYFRA21-1水平显著高于健康人,并且就CYFRA21-1 而言， NSCLC患者CYFRA21-1 水平显著高于小细胞癌(SCLC)患者(5.19±3.90) ng/mL和(3.07±2.42)ng/mL （P<0.01）。［结论］免疫放射分析法检测血清CYFRA21-1的水平对于提高肺癌检出率及其临床分型的鉴别诊断是非常有意义的。 |
| 关键词: 肺癌 CYFRA21-1 免疫放射分析法(IRMA),NSCLC 鳞癌 |
| DOI：10.11724/jdmu.2003.01.22 |
| 分类号:R734.2 |
| 基金项目: |
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| Study of clinical value of diagnosing lung cancer with section 19 of CYFRA 21-1 |
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LI Jing,QI Xiao-hui,CAI Xin-xia,ZHANG Hua-li
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Department of Nuclear Medicine the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China
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| Abstract: |
| Delving into the clinical value of diagnosing lung cancer with section 19 of CYFRA 21-1. ［Methods］ Conduct a survey on the content of CYFRA 21-1 with IRMA on 70 lung cancer patients and compare the result with the testing result on 40 BLD patients and 40 healthy people. ［Result］ CYFRA21-1 content in the serum of lung cancer patients is (4.64±3.68) ng/mL,the result on BLD patients is (2.19±0.80)ng/mL （P<0.01） for healthy people, the result is (1.71±0.74)ng/mL（P<0.01）. The CYFRA21-1 content in the serum of lung cancer patients are all markedly higher than that of healthy individuals, and as far as CYFRA21-1 is concemed, CYFRA21-1 level of NSCLC patients is remarkably higher than SCLC patients (5.19±3.90) ng/mL and (3.07±2.42) ng/mL（P<0.01）.［Conclusion］ It follows that the testing of CYFRA 21-1 level with IRMA is important in raising the rate of identifying lung cancer and the differential diagnosis of their clinical types |
| Key words: lung cancer CYFRA 21-1 IRMA |