尿β2-m、Alb、IgG对糖尿病肾病早期诊断的价值

Value of β2-m、Alb and IgG in urine in early diagnosis of diabetic nephropathy

关键词:  糖尿病肾病  尿微量蛋白  放射免疫

Key words:  diabetic nephropathy  radioimmunoassay  Alb  β2-m

摘要:

探讨尿β2-m、Alb、IgG对糖尿病肾病早期诊断的价值。［方法］采用放射免疫分析法检测39例正常人及72例糖尿病患者尿β2-m、Alb、IgG的质量浓度，并与血BUN、Cr等指标比较。［结果］糖尿病组尿β2-m、Alb、IgG的质量浓度量分别为(332.76±98.42) ng/mL、(27.37±10.64)、(8.57±3.04) μg/mL, 明显高于对照组（P值分别为<0.001, <0.001, <0.01）, 其阳性率均高于常规评价肾功能的指标如BUN、Cr等(与Cr比较，p值分别为<0.05, <0.01, <0.05)。在尿Alb阴性者中，有14例β2-m阳性。［结论］尿微量蛋白β２-m与Alb的联合检测有助于糖尿病肾病的早期诊断。

Abstract:

To explore the value of β2-m、Alb and IgG of urine in the early diagnosis of diabetic nephropathy. ［Methods］ The authors measured the urine level of β2-m、Alb and IgG in 39 normal cases and 72 patients with DN, and compared them with BUN and Cr in serum. ［Result］ The β2-m、Alb and IgG leve l of patients with DN are (332.76±98.42) ng/mL、(27.37±10.64) μg/mL and (8.57±3.04) μg/mL respectively, and higher than those in normal cases remarkably (the Ｐ value is <0.001,<0.001,<0.01 respectively) , the rate of patients whose urine level is positive are higher than BUN and Cr (the Ｐ value is <0.05,<0.01,<0.05 respectively). The β2-m levels are higher abnormally in 14 patients whose Alb level is negative . ［Conclusion］ The detection of urine β2-m、Alb and IgG are valuable in the early diagnosis of DN; the combined use of these three indexes can elevate the positive rate of DN diagnosis.