转铁蛋白受体和铁蛋白在缺铁性贫血诊断中的意义

The significance of serum transferrin receptor and ferrin in iron deficient anem ia

关键词:  转铁蛋白受体  铁蛋白  缺铁性贫血

Key words:  transferrin receptor  ferritin  iron deficient anemia

摘要:

探讨可溶性转铁蛋白受体(sTfR)、血清中铁蛋白(SF)在缺铁性贫血诊断中的意义。方法：分别应用免疫比浊法和化学发光法测定缺铁性贫血、隐性缺铁患者和正常对照组的转铁蛋白受体和铁蛋白。结果：缺铁性贫血组sTfR的值为7.23±4.52 mg/L,明显高于隐性缺铁组（2.43±0.77 mg/L,P＜0.01）和正常对照组（1.34±0.35 mg/L,P＜0.01）。缺铁性贫血组和隐性缺铁组的SF分别为：4.3±1.8μg/L，7.2±3.7μg/L，两组均明显低于对照组（46.5±18.2μg/L）。结论：sTfR是诊断缺铁性贫血的较敏感的指标，SF是诊断隐性缺铁可靠指标。联合检测sTfR和SF，尤其是计算sTfR/SF对于早期诊断缺铁性贫血具有重要意义

Abstract:

To study the significance of serum ferritin, transferrin receptor in the diagnostic of iron deficient anemia(IDA).Methods:Immunity nephelomethy method and chemilumine- scence method were being need to detect the targets of ferrin and transferrin receptor in three different groups, which were normal controls group, iron deficiency(ID) group and IDA group. Results:The level of sTfR (7.23±2.5 mg/L) in IDA goup was significantly higher than that of in ID group (2.43±0.77 mg/L) and controls group(1.34±0.35 mg/L). The level of SF in IDA and ID goup is 4.3±1.8μg/L,7.2±3.7μg/L respectively, which are significantly lower than that of controls group(46.5±18.2μg/L). Conclusion: sTfR is a new sensitive target in the diagnosis of IDA, SF is a helpful target in the diagnosis of ID. It has important significance to detect sTfR and SF at the same time, especially caculate sTfR/SF for diagnosing IDA early.