| 引用本文: | 班丽英,张洁,赵翌,刘基巍,周明臣,邹丽娟,苏成业.胎盘因子对化疗患者免疫及骨髓功能影响的Ⅱ期临床研究[J].大连医科大学学报,2001,23(1):. |
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| 胎盘因子对化疗患者免疫及骨髓功能影响的Ⅱ期临床研究 |
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班丽英1, 张洁1, 赵翌1, 刘基巍1, 周明臣2, 邹丽娟2, 苏成业3
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1.大连医科大学第一临床学院肿瘤科,辽宁,大连,116011;2.大连医科大学第二临床学院肿瘤放疗科,辽宁,大连,116027;3.卫生部大连医科大学临床药理学基地,辽宁,大连,116027
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| 摘要: |
| 目的:评价胎盘因子对化疗患者的免疫及骨髓功能的影响.方法:20例肿瘤化疗患者进行随机试验,试验组10例,对照组10例;用药(安慰剂或胎盘因子)于化疗前2d开始,4mgq.d.i.m.,化疗后4mgq.o.d.i.m.至化疗后1周停药.结果:试验组病人化疗后T4/T8与对照组比较,显著高于对照组(P＜0.05);化疗引起的骨髓抑制:试验组为40%,对照组为70%.结论:胎盘因子可提高化疗患者细胞免疫功能,并对化疗引起的骨髓抑制起保护作用. |
| 关键词: 胎盘因子 化疗 骨髓抑制 免疫功能 |
| DOI：10.11724/jdmu.2001.01.12 |
| 分类号:R730.53 |
| 基金项目: |
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| Phase II clinical trial of placental factor on the immuno-function and bone-marrow suppression induced by chemotherapy |
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BAN Li-ying,ZHANG jie,,LIU Ji-wei
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Department of Oncology,the first Affliated Hospital,Dalian Medical University,Dalian 116011, China)
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| Abstract: |
| To evaluate the effect of placental factor on the immunofunction and bone-marrow suppression induced by chemotherapy.Methods:20 cancer-chemotherapy patients were randomised into test group(10 cases),and control group(10 cases); Placetal agent or placental factor was given 2 days before chemotherapy,4 m.g.q.d 4 mg q.d.after chemotherapy q.o.d. until a week after chemotherapy finished. Results:T4/T8 in test group after chemotherapy is higher than that in control group(P＜0.05); The bone-marrow suppression in the test group and control group were 40%,70% respectively. Conclusion:Placental factor can improve the immunofunction, and prevent bone-marrow suppression induced by chemotherapy |
| Key words: placental factor chemotherapy bone-marrow suppression immunofunction |