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引用本文:	胡军,孔力,鲁春光,郝立宏,朱耀寰,刘耘,张立秋.“祛斑霜”治疗黄褐斑作用机制的临床及实验研究 [J].大连医科大学学报,2000,22(2):.

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“祛斑霜”治疗黄褐斑作用机制的临床及实验研究
胡军¹, 孔力², 鲁春光², 郝立宏³, 朱耀寰³, 刘耘³, 张立秋³
1.大连医科大学组胚学教研室，辽宁大连116027;2.大连医科大学组胚学教研室，辽宁大连116027;3.大连医科大学第二临床学院中医科，辽宁大连116027

摘要:

为探讨“祛斑霜”治疗黄褐斑的作用机制，对黄褐斑患者外用“祛斑霜”前后血清中SOD活性的变化以及皮肤外涂“祛斑霜”的小鼠局部皮肤组织液中SOD活性的变化进行了检测分析。结果表明，用药后黄褐斑患者血清及实验小鼠用药处皮肤组织液SOD活性均明显增高，表明提高机体SOD活性，清除多余超氧自由基，减少黑色素形成，是“祛斑霜”治疗黄褐斑的作用机制之一。

关键词: 祛斑霜黄褐斑超氧自由基(

DOI：10.11724/jdmu.2000.02.11

分类号:R758.4

基金项目:

The clinical and experiment study of the mechanism of the `Removing-macule Cream' in treating patients with chloasma

HU Jun,KONG Li,LU Chun-guang

Department of Histology and Embryology,Dalian Medical University,Dalian 116027,China

Abstract:

To inquire into the mechanism of the Removing-macule Cream' in treating patients with chloasma,we measured and analyzed the change of SOD in homognizer of the mice skin and inserum of the patients before and after treatment.The result showed that the level of SOD activity increased remarkably.The study showed that elevating SOD activity,clearing away the unnecessary O.2 to reduce the melanin formation is one of the mechanism of the `Removing-macule Cream'in treating patients with chloasma

Key words: Removing-macule Ceram,Superoxide dismutase(SOD),Superoxygen free radical(